Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.

Zipping and Unzipping: Protein Modifications Regulating Synaptonemal Complex Dynamics.
Trends Genet. 2017 Dec 28;:
Authors: Gao J, Colaiácovo MP
Abstract
The proteinaceous zipper-like structure known as the synaptonemal complex (SC), which forms between pairs of homologous chromosomes during meiosis from yeast to humans, plays important roles in promoting interhomolog crossover formation, regulating cessation of DNA double-strand break (DSB) formation following crossover designation, and ensuring accurate meiotic chromosome segregation. Recent studies are starting to reveal critical roles for different protein modifications in regulating SC dynamics. Protein SUMOylation, N-terminal acetylation, and phosphorylation have been shown to be essential for the regulated assembly and disassembly of the SC. Moreover, phosphorylation of specific SC components has been found to link changes in SC dynamics with meiotic recombination. This review highlights the latest findings on how protein modifications regulate SC dynamics and functions.
PMID: 29290403 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - December 28, 2017 Category: Genetics & Stem Cells Authors: Gao J, Colaiácovo MP Tags: Trends Genet Source Type: research