Negative regulation of MAVS-mediated innate immune response by ASC.

Negative regulation of MAVS-mediated innate immune response by ASC.
Mol Cell Biochem. 2017 Dec 26;:
Authors: Han Y, He X, Wei C, Song T, Zou L, Li Z, Ye J, Qi L, Li L, Zhong H, Wu F
Abstract
Stringent control of the type I interferon signaling pathways is critical to effective host immune responses, however, the molecular mechanisms that negatively regulate these pathways are still poorly understood. Here, we show that apoptosis speck-like protein (ASC), an adaptor protein of inflammasome complex, can inhibit IFN-β signaling response by interacting with mitochondrial antiviral signaling protein (MAVS). Importantly, ASC-specific siRNA knockdown enhanced virus-induced type I interferon production, with consequent reduction of virus replication. Taken together, these results suggest that ASC, as a negative regulator of the MAVS-mediated innate immunity, may play an important role in host protection upon virus infection.
PMID: 29280086 [PubMed - as supplied by publisher]

Source: Molecular and Cellular Biochemistry - December 26, 2017 Category: Biochemistry Authors: Han Y, He X, Wei C, Song T, Zou L, Li Z, Ye J, Qi L, Li L, Zhong H, Wu F Tags: Mol Cell Biochem Source Type: research