Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017 Utility and Limitations

ACS Chemical BiologyDOI: 10.1021/acschembio.7b00903
Source: ACS Chemical Biology - Category: Chemistry Authors: Source Type: research

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New research discovers that receptors in the nervous system that cause itchy skin also reside in the gut, explaining chronic IBS pain.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Irritable Bowel Syndrome Source Type: news
The objective was to determine whether changes in parathyroid hormone (PTH) levels are associated with changes in symptoms within this patient population.Study DesignProspective cohort.Setting &Participants165 adults with hyperparathyroidism secondary to kidney failure diagnosed, a range of dialysis vintages, and receiving regular hemodialysis from a US single-provider organization.ExposureChange in PTH levels over 24 weeks.Outcomes19 putative symptoms of secondary hyperparathyroidism measured up to 4 times using a self-administered questionnaire that assessed severity on a 5-level ordinal scale.Analytical ApproachLong...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Capsule Summary: Ruxolitinib cream improved Eczema Area Severity Index and Investigator ’s Global Assessment responses in patients with atopic dermatitis (AD), with rapid, sustained improvement in itch. Ruxolitinib cream may offer a novel and effective treatment for AD.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
In this study we evaluated the effects of protein extracts of probiotics in the amelioration of AR.MethodsExtracts ofBifidobacterium infantis (EBI) were prepared by lysing the live probiotics. AR mice were developed to be used to evaluate the therapeutic efficacy of EBI.ResultsThe results show that EBI induced interleukin (IL) ‐10‒producing dendritic cells (DCs) via increasing IL‐35 and signal transducer and activator of transcription 3 (STAT3) phosphorylation. IL‐10‒expressing DCs induced IL‐10‒producing B cells (B10 cells), with the latter showing immunosuppressive functions. After challenge with specific a...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
An older man was tormented by a rash that no one could diagnose — until he found a doctor who was known for unlocking difficult cases.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Itching Parasites Scabies Eczema common toxocariasis covert toxocariasis Albendazole Tests (Medical) Allergies Medicine and Health Source Type: news
Updated Date: Wed, 16 Oct 2019 00:00:00 EDT
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
Current patient-reported outcome measures for itch are limited and may not capture its full impact on health-related quality of life (HRQOL). We sought to develop, calibrate and validate banks of questions assessing the HRQOL impact of itch as part of Patient-Reported Outcomes Measurement Information System ® (PROMIS®). A systematic process of literature review, content-expert review, qualitative research, testing in a sample of 600 adults, classical test theory methods, and item response theory (IRT) analyses were applied.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Stasis dermatitis (SD) is a common disease in the elderly population, with pruritus being one of the bothersome symptoms. However, there are few therapeutic modalities available for SD-associated itch because little is known about its pathophysiological mechanism. Therefore, we sought to investigate the mediators of itch in SD using an immunofluorescence study on patient lesions focusing on IL-31. Ex vivo stimulation studies using murine peritoneal macrophages were also used to elucidate the pathological mechanisms of IL-31 generation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
CONCLUSION: A patient with HCC was successfully treated with pembrolizumab after experiencing adverse effects with nivolumab. PMID: 31612928 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
AbstractPurposeVulvovaginal atrophy (VVA) is a commonly reported issue among breast cancer patients, and its aetiology is multifactorial. Treatment is difficult in these women, particularly because the use of oestrogens has traditionally been discouraged. Vaginal laser treatment has been reported to improve symptoms. We aimed to assess the impact on symptoms and sexual function of vaginal laser in women with early breast cancer (EBC).MethodsWe performed a single-arm investigator initiated pilot study of female EBC patients with symptomatic VVA. A total of 3 vaginal laser treatments were administered 4  weeks apart. Qu...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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