Focus: Drug-related osteonecrosis of the jaw.
[Focus: Drug-related osteonecrosis of the jaw]. Presse Med. 2017 Dec 21;: Authors: Schmouchkovitch A, Remaud M, Simon H, Herry H, Le Toux G, Boisramé S Abstract Antiresorptives and antiangiogenics are treatments that have proven effective in oncology and the treatment of osteoporosis and they are increasingly prescribed. The care of these patients requires collaboration between the prescriber and the oral health professional to establish an optimized treatment plan. Therapeutic education of the patient is essential for him to understand the issues of good oral health and the adverse effects that can be caused by these treatments. The management is essentially based on the individual benefit/risk balance resulting from the general, local and inherent of the molecule risk factors. Management of drug-related osteonecrosis of the jaw should be as early as possible. PMID: 29275972 [PubMed - as supplied by publisher]
This study assessed the difference in health-related quality of life (HRQOL) between participants with a mild to moderate adult sagittal deformity (ASD) (sagittal vertical axis [SVA] ≤9.5 cm) and those with a marked deformity (SVA>9.5 cm). We also evaluated predisposing factors for a marked deformity. Summary of Background Data. Sagittal imbalance is closely associated with HRQOL for the patient. However, how the effect changes depending on the degree of imbalance has not been fully evaluated. The understanding of the predisposing factor associated with marked deformity also lacks. Methods. A total of 124 e...
ConclusionsIt was observed that extracts of S. hexaphylla inhibited both 5α -reductase type 2 and ARs. The results indicate that the use of S. hexaphylla extract in BPH is probably beneficial through 5α-reductase inhibition and α-adrenergic receptor blockade. In addition, apoptosis and autophagy were induced, and PCNA was downregulated after S. hexaphylla treatment. Therefore, it can be concluded that S. hexaphylla has a therapeutic effect on BPH.Graphical abstract
ConclusionWe found that osteoporosis is a serious public health challenge in mainland China. The findings in our study add insight into the epidemiology of osteoporosis and would be beneficial for the prevention and treatment of osteoporosis in mainland China.
ConclusionThese results add robust evidence to an increased odds of osteoporosis and fractures in COPD. Fractures in the COPDG occurred at higher BMD values than expected, suggesting that COPD may be an independent marker of fracture risk, reinforcing a need for regular osteoporosis screening with BMD measurement and prophylaxis of fractures in patients with this disorder.
Background: Trunk muscle endurance may be associated with balance and falls self-efficacy for people with osteoporosis. However, all previous studies have examined trunk muscle strength rather than endurance.Purpose: To explore the relationsh...
Publication date: Available online 4 December 2019Source: Orthopaedics &Traumatology: Surgery &ResearchAuthor(s): Gilles Jean Marie Pasquier, Denis Huten, Harold Common, Henri Migaud, Sophie PutmanAbstractIntramedullary stem extensions will need to be extracted during total knee arthroplasty (TKA) revisions, especially repeated ones. These stems have various designs and lengths, can be straight or offset, cemented (partially or totally) or cementless, smooth or rough. This diversity adds to the difficult of extracting them, which the surgeon must anticipate before starting the revision procedure. Porous metaphyseal...
CONCLUSION: Osteoporotic BMD and osteoporotic fracture history were significantly, and independently, associated with an increased occurrence of echogenic plaques. Ultrasonographic screening of the carotid artery may benefit patients with osteoporosis. PMID: 31787146 [PubMed - in process]
CONCLUSIONS: The expression profile of lncRNAs was significantly altered in femur and quadriceps of OVX rat models, which may offer new insights into pathogenesis of osteoporosis and sarcopenia and potentially provide novel therapeutic targets. PMID: 31789293 [PubMed - in process]
We present a 16-year-old Chinese male patient with the typical features of APS, such as progeroid manifestations, cutaneous mottled hyperpigmentation, generalized lipodystrophy, and severe metabolic complications. The patient has also been detected with some rare and severe skeletal features, such as severe osteoporosis, generalized thinning of cortical bone, and recurrent femoral fractures. Genetic mutation detection in theLMNA gene revealed a de novo heterozygous mutation, the c. 29C>T (p. T10I).
Hui Chen, Xue-Jian Wu A new two-dimensional CoII-containing coordination polymer has been prepared using a light-harvesting triphenylamine type organic ligand, which could be applied for the degradation of organic dyes assisted by H2O2. In addition, the anti-osteoporosis activity of this complex has been studied both experimentally and computationally.