Systemic sclerosis: Annual chest CT is not necessary for all patients.

Systemic sclerosis: Annual chest CT is not necessary for all patients. Presse Med. 2017 Dec 20;: Authors: Monnier-Cholley L, Rivière S, Barikalla AO, Mahevas T, Tiev KP, Arrivé L PMID: 29275021 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research

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ConclusionsLcSSc patients have a low mRSS at baseline with marginal changes with time. Conversely, SSc-ILD can be as progressive as in DcSSc supporting the inclusion of LcSSc patients in SSc-ILD trials and suggesting potential benefit of any anti-ILD drugs. Similarly, although slightly less common, DU should receive the same attention in the two subsets.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 December 2019Source: Autoimmunity ReviewsAuthor(s): Savino Sciascia, Irene Cecchi, Carlo Massara, Daniela Rossi, Massimo Radin, Pineda Lourdes Ladehesa, Francisco Guiñazu, Elena Rubini, Silvia Foddai, Paula Alba, Alejandro Escudero, Elisa Menegatti, Dario Roccatello
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionRTX is a promising therapeutic tool in CTD-related ILD. This systematic review remarks the unmet need of multicenter prospective studies aiming to evaluate the effectiveness of RTX with adequate sample size and study design.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Systemic sclerosis (SSc) is characterized by vascular alterations and extensive fibrosis of the skin, lungs and other internal organs. Although the pathogenesis of SSc has not been elucidated, B cell abnormalities likely play an important role [1]. CD19, a B ‐cell‐specific cell surface molecule that defines signal thresholds critical for humoral immune responses and autoimmunity, is overexpressed on B cells from patients with SSc [2]. In the tight-skin (TSK/+) mouse, a genetic model for human SSc, TSK/+ mice deficient in CD19 expression demonstrated significantly decreased skin fibrosis [3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Garmin Ltd. co-founder and Executive Chairman Min Kao has donated $20 million to a nonprofit Los Angeles hospital. The gift from the Kao Family Foundation will create the Kao Autoimmunity Institute to advance research and treatment of rheumatologic diseases at Cedars-Sinai Medical Center, according to a Tuesday release. The donation also will establish a program within the institute that provides training and education for people with scleroderma, a disease that causes chronic hardening and tightening…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 11 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Poupak Fallahi, Giusy Elia, Francesca Ragusa, Ilaria Ruffilli, Stefania Camastra, Claudia Giusti, Sabrina Rosaria Paparo, Debora Gonnella, Yehuda Shoenfeld, Silvia Martina Ferrari, Alessandro AntonelliAbstractAutoimmune thyroid diseases (AITD) are organ-specific autoimmune disorders mediated by Th1 lymphocytes, whose main clinical presentations are Hashimoto’s thyroiditis (HT), or Graves’ disease (GD). HT, GD, thyroid autoantibodies and thyroid dysfunctions have been shown in s...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Some people with rare diseases rely on peer-led support groups for disease-specific education and emotional and practical support. Systemic sclerosis (SSc), or scleroderma, is a rare autoimmune connective tiss...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
This case report describes 2 patients who presented with laryngeal complications after undergoing radiation therapy.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
DiscussionThe SPIN-SSLED trial will test whether a training program for SSc patient support group leaders increases the self-efficacy of group leaders to carry out leadership tasks. The program has the potential to significantly improve the effectiveness and sustainability of existing SSc support groups, to increase the number of available support groups, and to be adapted for other chronic diseases.Trial,NCT03965780. Registered on 29 May 2019.
Source: Trials - Category: Research Source Type: clinical trials
Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.However, when healing is disrupted — whether by chronic injury or disease — the cells that make up scar tissue can go rogue, continuously dividing and spreading until the scar eventually strangles the organ it was intended to help heal, which can lead to organ failure.That progressive, out-of-control scarring is called fibrosis, and it can occur in any organ in the body. Fibrosis plays a major role in many dis...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
More News: General Medicine | Scleroderma