Phenolic compounds from the leaves of Breynia officinalis and their tyrosinase and melanogenesis inhibitory activities

AbstractFrom the EtOAc-soluble fraction of a MeOH extract of the leaves ofBreynia officinalis, five new compounds (1–5) along with 11 known compounds (6–16) were isolated. The structures of the new compounds were elucidated by spectroscopic methods and compounds1–3 were found to be acylated hydroquinone apiofuranosylglucopyranosides, while compound4 was an acylated hydroquinone glucopyranoside. Compound5 was shown to be butylp-coumarate and this seems to be its first isolation from a natural source. The tyrosinase inhibitory activity of all of the isolated compounds was assayed, and the activity was significant inp-coumarate derivatives. The most active compound, compound3, also inhibited melanogenesis in an in vivo whole animal model, zebrafish.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research