The Cohort Multiple Randomised Controlled Trial (cmRCTs) design was found to be highly susceptible to low statistical power and internal validity biases

The ‘cohort multiple randomized controlled trial’ (cmRCT) is a recent innovation by which novel interventions are trialled within large longitudinal cohorts of patients to take gain efficiencies and align trials more closely to standard clinical practice. The use of cmRCTs is outpacing methodologica l understanding of them and more appropriate methods for designing and analysing such trials are urgently needed.
Source: Journal of Clinical Epidemiology - Category: Epidemiology Authors: Source Type: research