Urine albumin is a superior predictor of preeclampsia compared to urine plasminogen in type-1 diabetes patients

Pregnant women with type 1 diabetes (T1DM) are at increased risk of developing preeclampsia (PE). Plasminogen is aberrantly filtrated from plasma into tubular fluid in PE patients and activated to plasmin. Plasmin activates the epithelial sodium channel (ENaC) in the collecting ducts potentially causing impaired sodium excretion, suppression of the renin-angiotensin-aldosterone system and hypertension in PE.

http://www.ashjournal.com/article/S1933-1711(17)30416-3/fulltext?rss=yes

Source: Journal of the American Society of Hypertension - December 13, 2017 Category: Cardiology Authors: Lise Hald Nielsen, Boye L. Jensen, Jens Fuglsang, Lise lotte Torvin Andersen, Dorte M øller Jensen, Jan Stener Jørgensen, Gitte Kitlen, Per Ovesen Tags: Research Article Source Type: research