Alzheimer's Cases to Double by 2060: Report
As the baby boomer population ages, the number of Americans with Alzheimer's disease will double by 2060, researchers report.
Saatheeyavaane Bhuvanendran, Yatinesh Kumari, Iekhsan Othman, Mohd Farooq Shaikh
This article provides an up-to-date review of research evidence for hearing interventions, as well as recommendations for speech-language pathologists and audiologists to work together to ensure access to hearing health care and increased opportunities for meaningful life engagement for people with dementia and hearing loss. PMID: 29933487 [PubMed - in process]
Ranked #1 by Healthline in the Best Alzheimer's Blogs - 2012 - 2018"The Alzheimer ’s Reading Room is what it claims to be – and more.""This comprehensive site is run by full-time caregiver and gifted advocate Bob DeMarco. Filled with wonderful contributions from a variety of talented writers, this site offers everything you need to know about the challenge of caregiving, learning about your loved one ’s condition, and taking care of yourself as well. Thanks to the tireless efforts of everyone at the Alzheimer ’s Reading Room, you have a go-to place for advice, education, and...
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
This study indicates that breaking curcumin to nanosize produces improved effects on passive avoidance memory in adult mice accompanied with MMP-2, MMP-9, p-ERK, and p-JNK changes in the hippocampus.
Conclusion ADL displayed anti-neuroinflammatory activity in LPS-activated BV2 cells. The mechanism concerns its regulatory effect on the crosstalk between Nrf2 and p65. Graphical abstract
Early-onset Alzheimer ’s disease is a form of dementia that begins before the age of 65. Recognizing the initial symptoms can help a person seek treatment earlier and slow the progression of the disease. In this article, learn about ten signs of early-onset Alzheimer’s. We also cover how to help a loved one cope.
Sixteen years ago, we published an analytical model that projected the impact of a breakthrough drug for Alzheimer's disease.1 At that time, the enzyme that cleaves amyloid precursor protein had recently been identified,2 and it seemed reasonable to assume that a more effective treatment was on the near horizon.3–5 We modeled 2 scenarios: one in which the breakthrough drug delayed disease onset and the other in which the new drug slowed disease progression.
Discussion A unified CSF handling protocol is recommended to reduce preanalytical variability and facilitate comparison of CSF biomarkers across studies and laboratories. In future, experiments should use a gold standard with fresh CSF collected in low binding tubes.
Discussion Future studies should investigate the predictive, prognostic, and monitoring capacity of biomarkers to provide insight into the longitudinal course of agitation/aggression, as well as predict and monitor biological response to a pharmacological intervention.