Alzheimer's Cases to Double by 2060: Report

As the baby boomer population ages, the number of Americans with Alzheimer's disease will double by 2060, researchers report.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Cambridge University scientists along with a team in Sweden identified abnormal deposits called protein oligomers as the most likely cause of dementia.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Ohnishi T, Ohnishi ST, Salerno JC Abstract NADH-quinone oxidoreductase (complex I) is the largest and most complicated enzyme complex of the mitochondrial respiratory chain. It is the entry site into the respiratory chain for most of the reducing equivalents generated during metabolism, coupling electron transfer from NADH to quinone to proton translocation, which in turn drives ATP synthesis. Dysfunction of complex I is associated with neurodegenerative diseases such as Parkinson's and Alzheimer's, and it is proposed to be involved in aging. Complex I has one non-covalently bound FMN, eight to 10 iron-sul...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
(Natural News) Every 66 seconds, someone in the United States is diagnosed with Alzheimer’s. This translates to more than five million Americans living with the illness today; a number that is estimated to reach 16 million by 2050. Alzheimer’s is the sixth-leading cause of death in the U.S and is considered America’s most expensive disease. Despite advancing...
Source: - Category: Consumer Health News Source Type: news
Modified Criteria for Diagnosing "Cognitive Frailty". Psychiatry Investig. 2018 Sep;15(9):839-842 Authors: Won CW, Lee Y, Kim S, Yoo J, Kim M, Ng TP, Kim H, Son SJ Abstract The concept of cognitive frailty has recently been proposed by an International Consensus Group as the presence of physical frailty and cognitive impairment [defined using the Clinical Dementia Ratings (CDR)=0.5], without concurrent dementia. However, CDR is difficult to implement and not often available in epidemiologic studies or busy clinical settings, and an alternative to CDR is required. We suggest an alternative def...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
DISCUSSION: Our findings provide evidence for genetic overlap, mostly due to apolipoprotein E (APOE), between vascular pathologies and AD dementia. The association between AD polygenic risk and late-life cognition is mediated in part via effects on vascular pathologies. PMID: 30240575 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This report disseminates the research priorities that emerged from this conference, building on an earlier Gerontological Society of America preconference. We review key racial/ethnic differences in cognitive aging and dementia and identify current knowledge gaps in the field. We advocate for a systems-level framework for future research whereby environmental, sociocultural, behavioral, neuropathological, genetic, and psychometric levels of analysis are examined together to identify pathways and mechanisms that influence disparities. We then discuss steps to increase the recruitment and retention of racial/ethnic minoritie...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 21 September 2018Source: Stem Cell ResearchAuthor(s): Nicholas Brookhouser, Ping Zhang, Richard Caselli, Jean J. Kim, David A. BrafmanAbstractAlthough the majority of late-onset Alzheimer's disease (AD) patients are labeled sporadic, multiple genetic risk variants have been identified, the most powerful and prevalent of which is the e4 variant of the Apolipoprotein E (APOE) gene. Here, we generated human induced pluripotent stem cell (hiPSC) lines from the peripheral blood mononuclear cells (PBMCs) of a clinically diagnosed AD patient [ASUi005-A] and a non-demented control (NDC) patient [...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
In this study, we investigated the role of CHIT1 in TGFβ-Smad signaling and Aβ phagocytosis in N9 microglia. We found that CHIT1 significantly enhanced TGFβ1-induced expression of TβRI (TGFβ receptor I) and activation of Smad signaling. CHIT1 did not affect Aβ uptake in microglia by itself, but did enhance TGFβ1-induced phagocytosis of Aβ, which was blocked by pretreatment with SB431542 (TβRI inhibitor). These results indicate that CHIT1 may play a protective role in Aβ clearance by enhancing TGFβ signaling in microglia.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: Available online 20 September 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Vladimir I. Martynov, Alexey A. Pakhomov, Igor E. Deyev, Alexander G. PetrenkoAbstractBackgroundIntracellular pH underlies most cellular processes. There is emerging evidence of a pH-signaling role in plant cells and microorganisms. Dysregulation of pH is associated with human diseases, such as cancer and Alzheimer's disease.Scope of reviewIn this review, we attempt to provide a summary of the progress that has been made in the field during the past two decades. First, we present an overview of the c...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Abstract Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule binding repeats, named 3R-tau and 4R-tau, respectively. Dysregulation of tau exon 10 splicing could cause neurofibrillary degeneration. Acetylation is one of the major post-translational protein modifications in the cell by attachment of the acetyl group to either the α-amino group of the N-terminus of proteins or to the ε-amino group of lysine residues. Sirt1, one member in mammalian Sirtuin family, deacetylates protein and is associated closely with age-related diseases including Alzheimer's disease. ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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