Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy.

Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy. J Contemp Brachytherapy. 2017 Oct;9(5):418-423 Authors: Boman E, Paterson D, Huang J, Pearson S, Johnson C Abstract Purpose: Nylon 6/6 interstitial brachytherapy catheters may stretch when exposed to moisture, mechanical tension, and body temperature. The purpose of this study is to evaluate the magnitude of catheter stretch during a course of multi-catheter interstitial breast brachytherapy for nylon 6/6 treatment catheters, and to assess the impact this has on treatment plan dosimetry. Material and methods: Catheters were exposed to water at 37°C for six days and the internal catheter length change (ΔL_W) was measured daily. Additionally, the measured internal catheter length change (ΔL_P), performed prior to each treatment fraction, for seven interstitial breast brachytherapy patients (total of 76 catheters) were retrospectively analyzed. The maximum length change seen in ΔL_P and ΔL_W were introduced as a source positional error to retrospective treatment plans, and treatment plan dosimetry was analyzed. Results: ΔL_W and ΔL_P were on average +4.0% and +1.6% of the catheter lengths in water or tissue after 48 hours. Weak correlation was seen between the average ΔL_P per catheter and both the catheter length within tissue (ρ = 0.36, p = 0.0007), and the mid-catheter depth in tissue (&...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

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Prostate cancer is the most common type of cancer diagnosed in men [1 –3]. Permanent seed brachytherapy also known as low-dose-rate (LDR) brachytherapy is the standard option for low and intermediate risk prostate cancer [4,5]. LDR brachytherapy involves permanent implantation of radioactive sources (seeds) within the prostate gland. To evaluate the quality of the i mplant, post implant dosimetry is typically performed at day 30 following the implantation [6]. The implant quality is mainly assessed through Dose–Volume Histogram (DVH)-related parameters which have been reported to be dependent on the imaging modality [7].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Source Type: research
Over the last two decades, magnetic resonance imaging (MRI), with its excellent soft tissue-contrast, has been increasingly used for cancer staging, radiotherapy target delineation, treatment planning and treatment response monitoring. In the late 1990s MR image-guided adaptive brachytherapy (IGABT) was pioneered in cervix cancer [1 –4] and recommendations by the Groupe Européen de Curiethérapie and the European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) introduced MRI-based target concepts and 3D dose–volume evaluation and reporting [5,6].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original article Source Type: research
ieu L Abstract High dose rate (HDR) brachytherapy planning usually involves an iterative process of refining planning objectives until a clinically acceptable plan is produced. The purpose of this two-part study is to improve current planning practice by designing a novel inverse planning algorithm based on multi-criteria optimization (MCO). In the first part, complete Pareto surfaces were approximated and studied for prostate cases. A Pareto surface approximation algorithm was implemented within the framework of Inverse Planning Simulated Annealing (IPSA). The Pareto surfaces of 140 prostate cases were...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
ieu L Abstract The current iterative approach to inverse planning of high dose rate (HDR) treatment planning can be time consuming. The purpose of this two-part study is to streamline the planning process while maintaining plan quality. In this second part, a multi-criteria optimization (MCO) planning algorithm is proposed and benchmarked against a standard planning algorithm. With a set of previously established regression models, a patient-specific valid solution space on the Pareto surface was predicted based on the anchor plans results. Alternative plans generated alongside the partial Pareto front were p...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
up for Gynecologic Cancer A phase I study was performed to determine the recommended dose of carbon ion radiotherapy and 3D image-guided brachytherapy for histologically confirmed stage II (≥4 cm), III, or IVA cervical cancer. Dose-limiting toxicities (treatment-related toxicities occurring within three months from the start of carbon ion radiotherapy) included Grade 3 non-hematological toxicity, Grade 4 hematological toxicity, or interruption of treatment for more than two weeks due to treatment-related toxicities. Carbon ion radiotherapy consisted of whole-pelvic irradiation with 36.0 Gy (relative biological effec...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusion: Based on this data, the incidence of uveal melanoma in Ireland is high when compared with other reported incidence rates in Europe and worldwide. Relative and observed survival were in keeping with other reported European survival rates.Ocul Oncol Pathol
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
To propose a workflow that uses ultrasound (US)-measured skin –balloon distances and virtual structure creations in the treatment planning system to evaluate the maximum skin dose for patients treated with Contura Multi-Lumen Balloon applicators.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
To assess the feasibility of high-dose-rate perioperative multicatheter interstitial brachytherapy to deliver accelerated partial breast irradiation (APBI) in selected patients with early breast cancer.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
This study tried to determine an accurate dosimetric data set for this source using Monte Carlo (MC) simulations along with detailed uncertainty analysis. To explore how different dosimetric data sets can make changes in practical situations, clinical dose distributions based on our results were compared with the dose distributions derived from Granero et  al.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
To compare radiation toxicity in endometrial cancer patients treated with adjuvant vaginal brachytherapy (VBT) vs. VBT with concurrent chemotherapy (CCT) or sequential chemotherapy (SCT)
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
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