Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy.
Treatment plan dosimetric impact after catheter stretch during multi-catheter interstitial breast brachytherapy. J Contemp Brachytherapy. 2017 Oct;9(5):418-423 Authors: Boman E, Paterson D, Huang J, Pearson S, Johnson C Abstract Purpose: Nylon 6/6 interstitial brachytherapy catheters may stretch when exposed to moisture, mechanical tension, and body temperature. The purpose of this study is to evaluate the magnitude of catheter stretch during a course of multi-catheter interstitial breast brachytherapy for nylon 6/6 treatment catheters, and to assess the impact this has on treatment plan dosimetry. Material and methods: Catheters were exposed to water at 37°C for six days and the internal catheter length change (ΔL_W) was measured daily. Additionally, the measured internal catheter length change (ΔL_P), performed prior to each treatment fraction, for seven interstitial breast brachytherapy patients (total of 76 catheters) were retrospectively analyzed. The maximum length change seen in ΔL_P and ΔL_W were introduced as a source positional error to retrospective treatment plans, and treatment plan dosimetry was analyzed. Results: ΔL_W and ΔL_P were on average +4.0% and +1.6% of the catheter lengths in water or tissue after 48 hours. Weak correlation was seen between the average ΔL_P per catheter and both the catheter length within tissue (ρ = 0.36, p = 0.0007), and the mid-catheter depth in tissue (&...
Conditions: Hepatocellular Carcinoma; Hepatocellular Carcinoma Non-resectable Intervention: Device: Selective Internal Radiation Therapy with QuiremSpheres® Sponsor: Terumo Europe N.V. Recruiting
Purpose: To report the efficacy and late side effects(LSEs) of CT-based image-guided brachytherapy for the treatment of cervical cancer.Materials: Between 2008 and 2014, 100 patients with FIGO stage IIB-IVA cervical carcinoma were analyzed. The patients received pelvic irradiation (45-50 Gy in 25 fractions) with concurrent chemotherapy, whereas the mean prescribed EBRT dose, including initial and boost doses to positive lymph nodes, ranged from 54 to 64 Gy. Afterwards, intracavitary(IC) or combined intracavitary/interstitial(IC/IS) brachytherapy was performed using a CT-based procedure with prescribed doses of 6 or 8 Gy in...
Conclusions: Kilovoltage surface brachytherapy is an applicable and reproducible tool in the treatment of squamous cell carcinoma of ocular conjunctiva. The administered doses are well tolerated by patients with low levels of acute toxicity. Longer follow-up is needed to establish disease control rates and late toxicities. PMID: 29910832 [PubMed]
Introduction: Locally advanced pancreatic cancer (LAPC) is associated with a poor prognosis. Current standard treatment is limited to chemotherapy or chemo-radiotherapy. Novel treatment approaches are crucial in attempting to combat this unmet medical need. Phosphorus-32 (P-32) Microparticles is a brachytherapy device that implants a predetermined dose of the beta radiation emitting isotope (P-32) directly into pancreatic tumours via endoscopic ultrasound (EUS) guidance. The presented data are early results from an ongoing international, multi-institutional, single-arm pilot study. The study objective is to determine the s...
To improve efficiency, convenience, and cost, a prospective phase II trial was initiated to evaluate accelerated partial breast irradiation delivered with noninvasive image-guided breast brachytherapy (NIBB) via five once-daily fractions.
We analyzed factors associated with rectal toxicity after iodine-125 prostate brachytherapy (BT) with or without external beam radiation therapy (EBRT).
“Quadrella” index has been recently developed to assess oncological and functional outcomes after prostate brachytherapy (PB). We aimed to evaluate this index at 1, 2, and 3 years, using validated questionnaires, assessed prospectively.
Introduction: SORAMIC is an RCT comprising diagnostic, local ablation and palliative studies. Based on the result of the diagnostic study patients were assigned to either the local ablation or palliative cohort. The palliative cohort (reported here) was designed to determine the efficacy and safety of combining SIRT (Selective Internal Radiation Therapy) with sorafenib in patients with advanced HCC.
Introduction: Selective Internal Radiation Therapy (SIRT) involves hepatic intra-arterial infusion of β-particle emitting Yttrium-90 labelled microspheres. SIRT increases first line response rates (RR) and hepatic progression free survival (hPFS) in liver predominant metastatic colorectal cancer (mCRC) patients treated with oxaliplatin/5FU/folinic acid (FOLFOX). SIRT is often used in pre-treated mC RC patients with peri-procedural FOLFOX to achieve radio-sensitization and control extra-hepatic disease. Since 2009 we have used FOLFIRI as an alternative peri-procedural regimen with SIRT.
An innovative template, based on thoracic cage surface reconstructions for breast interstitial brachytherapy was developed. Hybrid-inverse-planning-optimisation-based implantations and brachytherapy plans, using three custom anthropomorphic breast phantoms, were utilised for its validation. A user independent, inverse planning and inverse implanting technique is proposed.