New Breast Cancer Drug May Help Younger Women, Too

Adding a new drug to standard treatment can slow the progression of advanced breast cancer in younger women, a new clinical trial has found.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Authors: Zhou J, Zheng S, Liu T, Liu Q, Chen Y, Ma R, Tan D, Lu X Abstract Although M2 tumour-associated macrophages (M2 TAMs) have been shown to be associated with the progression and metastasis of breast cancer, their role in oesophageal squamous cell carcinoma (ESCC) remains less well understood. Therefore, to understand the clinicopathological significance of infiltrated M2 TAMs in ESCC, statistical analysis was performed after immunohistochemical evaluation of CD163 expression, a well-accepted surface marker of M2 TAMs in ESCC. To gain insight into the effect of M2 TAMs, ESCC cell lines Eca109 and KYSE150 cell...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Three female tech entrepreneurs shared their entrepreneurial journeys Monday evening, from dealing with self-doubt to running a business during breast cancer treatment. The local entrepreneurs who spoke as part of Global Entrepreneurship Week:  Dr. Kim Gandy is CEO and founder of Play-it Health, which developed an adherence platform with incentives for transplant patients and those with chronic conditions. Linda Van Horn is CEO and founder of iShare Medical, wh ich provides secure, HIPAA-compliant…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Kata Carter was diagnosed with breast cancer when her youngest daughter was three-months-old.
Source: ABC News: Health - Category: Consumer Health News Tags: GMA Source Type: news
Conclusion: Our analysis provides a rationale for the routine use of a radiopaque tissue transfer system for specimen radiography in BCS after neoadjuvant chemotherapy for invasive breast cancer in order to reduce re-excision rates.Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Conclusions: The lack of randomized controlled data, especially in high-risk patients, demonstrates the necessity for a registry study on this topic. Our survey describes, in detail, the indications for lipofilling as well as its appropriate application in breast cancer patients in Germany and may thereby reduce the present therapeutic uncertainties.Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Background: The aim of this study was to investigate the immunohistochemical expression of ribosomal protein (RP) S6-pS240 in non-special type invasive breast cancer in relation to other prognostic markers and gain new insights to facilitate more individualized treatment.Methods: The following clinical and histopathological parameters of 120 patients were determined: S6-pS240 expression, age, menopausal status, tumor size and grade, TNM stage, Nottingham Prognostic Index (NPI), lymph node stage, estrogen and progesterone receptor (ER/PR) expression, HER2/neu amplification, lymphovascular invasion, and proliferative index a...
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Conclusion: Within the overall goal to establish operating procedures for breast cancer immunotherapy, we propose to re-evaluate testing for deficient mismatch repair and to further intensify the search for biomarkers predictive for the success of immune checkpoint modulation including all tumor biologic subtypes of breast cancer.Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
Conclusion: CDK4/6 inhibitors exhibit a high therapeutic potential, although reliable prognostic markers need to be identified.Breast Care
Source: Breast Care - Category: Cancer & Oncology Source Type: research
(MedPage Today) -- Resolution aimed at women with dense breasts
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
This study aims to explore the possible molecular mechanisms underlying the relapse of breast cancer patients with early postoperative fever. Our results indicated plasma levels of lncRNA MALAT1 were elevated in breast cancer patients with early postoperative fever and were associated with RFS. Lipopolysaccharide (LPS) was able to induce fever and systemic inflammatory responses in 4T1 xenograft mice, and promote lung metastasis. But after knocking down lncRNA MALAT1, the inflammatory responses and metastasis of lung were significantly reduced. Moreover, after knocking down lncRNA MALAT1 in the 4T1 cells, TNF-α level...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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