PGC-1 α functions as a co-suppressor of XBP1s to regulate glucose metabolism

Conclusions Our findings reveal a novel function of PGC-1α as a suppressor of XBP1s function, suggesting that hepatic PGC-1α promotes gluconeogenesis through multiple pathways as a co-activator for HNF4α and FoxO1 and also as a suppressor for anti-gluconeogenic transcription factor XBP1s.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research