Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal

Conclusion In summary, mitophagy may be enhanced in endurance-trained runners based on elevated markers of mitophagy and mitochondrial dynamics. The HFM did not alter autophagy or mitophagy in either group. The absence of a relationship between mitophagy markers and metabolic flexibility suggests that mitophagy is not a key determinant of metabolic flexibility in a healthy population, but further investigation is warranted.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research