The necessity of external validation in exhaled breath research: a case study of sarcoidosis

In this study, we hypothesized that sarcoidosis
patients and healthy controls could be discriminated based on a group of volatile organic compounds
(VOCs) in exhaled breath and that these discriminating VOCs could be validated in an external
population. The first dataset consisted of 87 sarcoidosis patients and 27 healthy controls, whereas
the validation dataset consisted of 25 patients and 29 controls. Using the first dataset, nine VOCs
were found that cou...

Source: Journal of Breath Research - November 29, 2017 Category: Respiratory Medicine Authors: Rianne R R Fijten, Agnieszka Smolinska, Marjolein Drent, Jan W Dallinga, Remy Mostard, Dani ëlle M Pachen, Frederik J van Schooten and Agnes W Boots Source Type: research