t-Darpp activates IGF-1R signaling to regulate glucose metabolism in trastuzumab-resistant breast cancer cells.

CONCLUSIONS: t-Darpp activates IGF-1R signaling through heterodimerization with EGFR and HER2 to stimulate glycolysis and confer trastuzumab resistance. PMID: 29180608 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29180608?dopt=Abstract

Source: Clinical Cancer Research - November 27, 2017 Category: Cancer & Oncology Authors: Lenz G, Hamilton A, Geng S, Hong T, Kalkum M, Momand J, Kane SE, Huss J Tags: Clin Cancer Res Source Type: research