An inflammatory environment containing TNF α favors Tet2-mutant clonal hematopoiesis

• Inactivating TET2 mutations are common drivers of clonal hematopoiesis with aging• TNFα is increased in myelodysplastic syndromes and unhealthy aging• Loss of Tet2 increases murine bone marrow colony formation in the presence of TNFα• Human TET2-mutant bone marrow is resistant to colony- suppressive effects of TNFα• TET2-mutant clones may have greater fitness in an inflammatory environment of aging
Source: Experimental Hematology - Category: Hematology Authors: Tags: Brief Communications Source Type: research