Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication.

We report herein that papillomavirus protein E2 binds to NM1 and co-precipitates with the WSTF and SNF2h proteins. Our data suggest that E2 associates with the cellular B-WICH complex through binding to NM1. E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. The cellular multifunctional protein Brd4 and beta-actin are also present in the NM1-E2 complex. NM1 downregulation by siRNA increases the replication of the BPV1 and HPV5 genomes but does not affect HPV18 genome replication. These results suggest that the B-WICH complex may play a role in the papillomavirus life cycle through NM1 and E2 protein interaction.
PMID: 29179037 [PubMed - as supplied by publisher]

Source: Virology - November 24, 2017 Category: Virology Authors: Sankovski E, Abroi A, Ustav M, Ustav M Tags: Virology Source Type: research