Impact of macroprolactin on galactorrhea and the rate of patients possibly affected by macroprolactin.

Impact of macroprolactin on galactorrhea and the rate of patients possibly affected by macroprolactin.
Endocr J. 2017 Nov 22;:
Authors: Aisaka K, Tsuchiya F, Sueta M, Itabashi K, Nose S, Hasegawa A, Obata S, Hiraike H, Yokoyama T
Abstract
The clinical influence of macroprolactin (MPRL) is not clearly understood and the rate of patients potentially affected by MPRL is unknown. We investigated the influence of MPRL on the onset of galactorrhea and estimated the rate of patients with a proportion of MPRL fraction that may possibly affect galactorrhea. Data of patients with obstetric or gynecological symptoms who had undergone PRL fractionation testing were retrospectively analyzed. To evaluate factors influencing galactorrhea, a multivariate logistic regression analysis was performed and the adjusted odds ratios of MPRL for galactorrhea were calculated. Cutoff values for the total PRL level and the proportion of MPRL fractions for galactorrhea were determined by ROC analysis using a multivariate logistic model. The prevalence of patients with a proportion of MPRL fraction greater than or equal to the cutoff value for galactorrhea was estimated. The median proportion of MPRL fraction was 30.1% and increased as PRL level increased. Total PRL and MPRL had a significant influence on the onset of galactorrhea and the adjusted odds ratio was 1.09 in total PRL and 0.94 in MPRL. The rate of patients with a proportion of MPRL fraction that may p...

Source: Endocrine Journal - November 23, 2017 Category: Endocrinology Tags: Endocr J Source Type: research