Understanding missing proteins: a functional perspective.

Understanding missing proteins: a functional perspective. Drug Discov Today. 2017 Nov 17;: Authors: Zhou L, Wong L, Goh WWB Abstract A missing protein (MP) is an unconfirmed genetic sequence for which a protein product is not yet detected. Currently, MPs are tiered based on supporting evidence mainly in the form of protein existence (PE) classification. As we discuss here, this definition is overly restrictive because proteins go missing in day-to-day proteomics as a result of low abundance, lack of sequence specificity, splice variants, and so on. Thus, we propose a broader functional classification of MPs that complements PE classification, discuss major causes, and examine three corresponding solution tiers:. biological, technical, and informatics. We assert that informatics-driven solutions would have a major role in resolving the MP problem (MPP). PMID: 29158195 [PubMed - as supplied by publisher]
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research