Benzophenone derivatives from the plant endophytic fungus, Pestalotiopsis sp.

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Ren-Yu Song, Yi Liu, Rui-Huan Liu, Xiao-Bing Wang, Tian-Xiao Li, Ling-Yi Kong, Ming-Hua Yang Two new (1–2) and one known (3) benzophenone derivatives, along with five known ambuic acid analogues (4–8) were isolated from the solid cultures of a Pestalotiopsis sp. Compound 2 represented both enantiomeric and atropisomeric isomers, and the absolute configurations of enantiomers [(−)-2 and (+)-2] were determined by electronic circular dichroism (ECD) calculations. All the isolates were evaluated for their antimicrobial and cytotoxic activities. Chlorinated compounds 2 and 3 showed potent antimicrobial activities against four pathogenic bacteria, and compound 3 also displayed strong antifungal activity against Candida glabrata (ATCC 90030) with an MIC50 value of 2.6±0.1μg/mL. Compound 1 exhibited moderate cytotoxicity against U2OS and MCF-7 with IC50 values of 11.6 and 16.8μM, respectively. Graphical abstract

Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research