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Voices: A Gay Husband, a Dire Diagnosis and the Best-Laid Plans

I was just as unprepared to hear my doctor say “ lung cancer ” as I had been to hear my husband say “ I ’ m gay. ”
Source: NYT Health - Category: Consumer Health News Authors: Tags: Lung Cancer Homosexuality and Bisexuality Respiratory System Lungs Source Type: news

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The Marion, South Carolina, city administrator and its fire chief have been indicted on charges of knowingly exposing staff, volunteer workers and community members to toxic asbestos. Both were granted a personal recognizance bond at their arraignment Nov. 17 in the Marion County Courthouse. City Administrator Alan Thomas Ammons and Fire Chief Ralph Walton Cooper III were charged with misconduct in office, conspiracy to violate the Pollution Control Act, and violation of the Pollution Control Act. All three indictments — signed by South Carolina Attorney General Alan Wilson — were filed Nov. 2, 2017. The alleg...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Alan Thomas Ammons Alan Wilson asbestos exposure Ashley Brady Marion Fire Station Pollution Control Act Ralph Walton Cooper South Carolina Department of Health and Environmental Control Source Type: news
Condition:   Advanced Non Small Cell Lung Cancer Interventions:   Drug: Nivolumab + Ipilimumab;   Drug: Chemotherapy Sponsor:   Rennes University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research
ConclusionMetabolic response by18F –FDG was effective in predicting efficacy and survival at 1 month after nivolumab treatment.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.7b00329
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Authors: Liu X, Huang YG, Jin CG, Zhou YC, Chen XQ, Li J, Chen Y, Li M, Yao Q, Li K, Lan M, Ye JG, Wang XC Abstract Abnormal microRNA-370 (miR-370) expression has been frequently reported in several types of cancers, including lung cancer. However, the role and molecular mechanisms of miR-370 in regulating the growth and metastasis of lung cancer have not been clarified. Here, we show higher levels of epidermal growth factor receptor (EGFR), but lower levels of miR-370 expression in most human lung cancer cells and non-tumor cells. Induction of miR-370 over-expression significantly reduced the levels of EGFR expres...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Lv G, Zhu H, Li C, Wang J, Zhao D, Li S, Ma L, Sun G, Li F, Zhao Y, Gao Y Abstract Transmembrane protein 98 (TMEM98), known as a novel gene related to lung cancer, hepatocellular carcinoma, differentiation of T helper 1 cells and normal eye development, has no defined role reported in terms of atherosclerosis (AS). To investigate the potential involvement of TMEM98 during AS processes, its obvious secretion and expression has been initially characterized in hyperlipidemia patients' serum and AS mice's serum respectively. We then explored the possible role of TMEM98 in the pathogenesis of AS in vitro. IL-8,...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Garcia J, Dusserre E, Cheynet V, Bringuier PP, Brengle-Pesce K, Wozny AS, Rodriguez-Lafrasse C, Freyer G, Brevet M, Payen L, Couraud S Abstract Non invasive somatic detection assays are suitable for repetitive tumor characterization or for detecting the appearance of somatic resistance during lung cancer. Molecular diagnosis based on circulating free DNA (cfDNA) offers the opportunity to track the genomic evolution of the tumor, and was chosen to assess the molecular profile of several EGFR alterations, including deletions in exon 19 (delEX19), the L858R substitution on exon 21 and the EGFR resistance muta...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
We report that eATP increased iATP levels and promoted drug resistance to various tyrosine kinase inhibitors (TKIs) and chemo-drugs in human cancer cell lines of five cancer types. In A549 lung cancer cells, the resistance was downregulated by macropinocytosis inhibition or siRNA knockdown of PAK1, an essential macropinocytosis enzyme. The elevated iATP upregulated the efflux activity of ABC transporters in A549 and SK-Hep-1 cells as well as phosphorylation of PDGFRα and proteins in the PDGFR-mediated Akt-mTOR and Raf-MEK signaling pathways in A549 cells. Similar phosphorylation upregulations were found in A549 tumor...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we applied some reliable machine learning algorithms to analyze data retrieved from patients who had one of six cancer subtypes (breast cancer, colorectal cancer, glioblastoma, hepatobiliary cancer, lung cancer and pancreatic cancer) as well as healthy persons. Quantitative gene expression profiles were used to encode each sample. Then, they were analyzed by the maximum relevance minimum redundancy method. Two feature lists were obtained in which genes were ranked rigorously. The incremental feature selection method was applied to the mRMR feature list to extract the optimal feature subset, which can be used...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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