In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents

AbstractIncreasing resistance to antibiotics is a major problem worldwide and stimulates the development of new bacterial inhibitors. Series of oxazolo[4,5-b]pyridine synthesized in our lab was examined to screen them as potential antimicrobial agents. The antimicrobial analyses of the synthesized compound were based on minimum inhibitory concentration determination, against four strains of bacteria. The results showed that the synthesized compounds have elicited good activity profile against methicillin-resistantStaphylococcus aureus (S. aureus), the bacterium that is largely responsible for hospital-acquired infections. Moreover, synthesized compounds were also docked against enterotoxin protein ofS. aureus which belongs toStaphylococcal enterotoxin type A(SEA). In vitro and in silico studies revealed that compounds3d,3g, and3h have demonstrated significant antibacterial activity in comparison to the standard control drug ampicillin and streptomycin.

Source: Medicinal Chemistry Research - November 7, 2017 Category: Chemistry Source Type: research