Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody

In conclusion, the anti-PSMA antibody is suitable as an APC for NIR-PIT. Furthermore, NIR-PIT with the anti-PSMA-IR700 antibody is a promising candidate of the treatment of PSMA-expressing tumors and could be readily translated to humans.
Implications: NIR-infrared photoimmunotherapy (NIR-PIT) using a fully human anti-PSMA-IR700 conjugate showed potential therapeutic effects against a PSMA-expressing prostate cancer that is readily translated to humans. Mol Cancer Res; 15(9); 1153–62. ©2017 AACR.

Source: Molecular Cancer Research - August 31, 2017 Category: Cancer & Oncology Authors: Nagaya, T., Nakamura, Y., Okuyama, S., Ogata, F., Maruoka, Y., Choyke, P. L., Kobayashi, H. Tags: Cell Death and Survival Source Type: research