Aberrant Patterns of Key Epithelial Basement Membrane Components in Keratoconus

Conclusions: These results indicate the activation of keratocytes into the fibroblast and myofibroblast wound phenotypes and the potential source of corneal scarring commonly observed in keratoconic corneas. Our data also support the hypothesis of dysregulated collagen synthesis and breakdown in the keratoconic cornea, in particular, the BM, and suggest a role for the BM in initiation and progression of keratoconus.

Source: Cornea - November 3, 2017 Category: Opthalmology Tags: Basic Investigation Source Type: research