CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas.

CONCLUSIONS: Human AS contain a small aggressive CD31(low) population that have lost part of their endothelial differentiation programs and are more resistant against oxidative stress and DNA damage due to intensified YAP signaling. Our finding that the addition of YAP inhibitors can re-sensitize CD31(low) cells towards doxorubicin may aid in the rational development of novel combination therapies to treat AS.
PMID: 29084920 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 30, 2017 Category: Cancer & Oncology Authors: Venkataramani V, Küffer S, Cheung KCP, Jiang X, Trümper LHP, Wulf GG, Ströbel P Tags: Clin Cancer Res Source Type: research