3D printed orodispersible films with Aripiprazole

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Witold Jamróz, Mateusz Kurek, Ewelina Łyszczarz, Joanna Szafraniec, Justyna Knapik-Kowalczuk, Karolina Syrek, Marian Paluch, Renata Jachowicz Three dimensional printing technology is gaining in importance because of its increasing availability and wide applications. One of the three dimensional printing techniques is Fused Deposition Modelling (FDM) which works on the basis of hot melt extrusion–well known in the pharmaceutical technology. Combination of fused deposition modelling with preparation of the orodispersible film with poorly water soluble substance such as aripiprazole seems to be extra advantageous in terms of dissolution rate. 3D printed as well as casted films were compared in terms of physicochemical and mechanical properties. Moreover, drug-free films were prepared to evaluate the impact of the extrusion process and aripiprazole presence on the film properties. X-ray diffractometry and thermal analyses confirmed transition of aripiprazole into amorphous state during film preparation using 3D printing technique. Amorphization of the aripiprazole and porous structure of printed film led to increased dissolution rate in comparison to casted films, which, however have slightly better mechanical properties due to their continuous structure. It can be concluded that fused deposition modelling is suitable technique and polyvinyl alcohol is a...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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“Summer means happy times and good sunshine. It means going to the beach, going to Disneyland, having fun.” – Brian Wilson “Summertime, and the livin’ is easy…” Great lyrics by George Gershwin from the classic song he wrote for the 1935 musical Porgy and Bess. Summertime should be a time for individuals, families and friends to spend together doing what makes them laugh, enjoy each other’s’ company, and contribute to everyone’s overall well-being. In the middle of vacation or weekend getaway planning, or just carving time out of your busy schedule for some fun ac...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Habits Happiness Source Type: blogs
This study examined the prevalence and associated factors of risky sexual behaviours among 1648 school-going adolescents using the 2012 Ghana Global School-based Student Health Survey. Our findings showed 33.5% of the participants had ever had sex 32.5% had multiple sexual partners and only 26.2% reported using condom during their last sexual intercourse. Being male, older age, anxiety, loneliness, suicidal ideation, being bullied, food insecurity (hunger), current alcohol and marijuana use were significant risk factors for being sexually experienced, multiple partners, but not condom use. Parental knowledge of activity wa...
Source: Journal of Adolescence - Category: Child Development Source Type: research
Publication date: Available online 21 July 2018Source: European Polymer JournalAuthor(s): Shuijiao Peng, Shuxuan Liu, Yujun Sun, Nanping Xiang, Xiancai Jiang, Linxi HouAbstractThe facile preparation of hydrogel electrolyte with high strength, healing ability and thermoplasticity is important and still remains a great challenge. In this paper, a novel way for the preparation of poly(vinyl alcohol) (PVA) supramolecular hydrogel electrolyte was presented. The PVA hydrogel electrolyte was prepared via the hydrogen bonding and salting-out effect. The high performance PVA-NaCl-glycerol hydrogel electrolyte could be obtained by t...
Source: European Polymer Journal - Category: Chemistry Source Type: research
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Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Publication date: 15 October 2018Source: Biosensors and Bioelectronics, Volume 117Author(s): Ahmed Y. El-Moghazy, Cunyi Zhao, Georges Istamboulie, Noha Amaly, Yang Si, Thierry Noguer, Gang SunAbstractAn ultrasensitive label-free amperometric immunosensor for the detection of chloramphenicol (CAP) residues in milk has been developed by using a screen-printed carbon electrode laminated with a layer of poly (vinyl alcohol-co-ethylene) (PVA-co-PE) nanofibrous membrane that is covalently immobilized with a CAP antibody (anti-CAP). The performance of the PVA-co-PE nanofiber membrane (PVA-co-PE NFM) on the electrode was compared ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Science and Medicine in SportAuthor(s): Samantha M. McDonald, Jihong Liu, Sara Wilcox, Xuemei Sui, Russell R. PateAbstractObjectivesMaternal body mass index (BMI) is a significant determinant of infant macrosomia. Given the strong metabolic effects of physical activity (PA), independent of body mass, it is unclear as to whether maternal PA may affect the risk of delivering a macrosomic infant. Thus, the purpose of this study was to determine if maternal PA moderates the relationship between maternal BMI and infant macrosomia.DesignCross-sectional study using...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Liver disease deaths are growing more common in the U.S. and disproportionately affecting younger Americans, according to a recent study. The paper, published in The BMJ just a day after a Centers for Disease Control and Prevention (CDC) report on rising liver cancer death rates, paints a troubling picture of how Americans’ drinking habits may be affecting their health. While the new study couldn’t prove causation, the researchers say drinking is likely to blame for the growing number of adults aged 24 to 35 who are dying from cirrhosis, or scarring of the liver. The researchers used deaths logged in the CDC&r...
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Publication date: Available online 5 April 2018Source: Journal of Materials Science &TechnologyAuthor(s): Jiaming Fan, Shiai XuAbstractA thin layer of poly (vinyl alcohol) (PVA) was coated on the surface of silicon carbide whiskers (SCWs) and crosslinked by glutaraldehyde, and then these modified whiskers (mSCWs) were incorporated into high density polyethylene (HDPE) to prepare HDPE/mSCW composites with a high thermal conductivity. The thermal conductivity, mechanical properties, heat resistance, thermal stability and morphology of HDPE/mSCW and HDPE/SCW composites were characterized and compared. The results reveal t...
Source: Journal of Materials Science and Technology - Category: Materials Science Source Type: research
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Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: 1 November 2018Source: Journal of Non-Crystalline Solids, Volume 499Author(s): Steve De Pooter, Steven Latré, Frederik Desplentere, David SevenoAbstractSilica aerogels are considered as promising materials for future energy saving buildings, however, their reliability remains questionable as commercially available aerogels can show relatively high standard deviations e.g. 22.2 ± 1.4 mW m−1 K−1. Therefore a synthesis protocol for silica aerogel powder with thermal conductivities having extremely reduced standard deviations was designed, compatible with mass production, i...
Source: Journal of Non Crystalline Solids - Category: Chemistry Source Type: research
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