3D printed orodispersible films with Aripiprazole

Publication date: 30 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 2 Author(s): Witold Jamróz, Mateusz Kurek, Ewelina Łyszczarz, Joanna Szafraniec, Justyna Knapik-Kowalczuk, Karolina Syrek, Marian Paluch, Renata Jachowicz Three dimensional printing technology is gaining in importance because of its increasing availability and wide applications. One of the three dimensional printing techniques is Fused Deposition Modelling (FDM) which works on the basis of hot melt extrusion–well known in the pharmaceutical technology. Combination of fused deposition modelling with preparation of the orodispersible film with poorly water soluble substance such as aripiprazole seems to be extra advantageous in terms of dissolution rate. 3D printed as well as casted films were compared in terms of physicochemical and mechanical properties. Moreover, drug-free films were prepared to evaluate the impact of the extrusion process and aripiprazole presence on the film properties. X-ray diffractometry and thermal analyses confirmed transition of aripiprazole into amorphous state during film preparation using 3D printing technique. Amorphization of the aripiprazole and porous structure of printed film led to increased dissolution rate in comparison to casted films, which, however have slightly better mechanical properties due to their continuous structure. It can be concluded that fused deposition modelling is suitable technique and polyvinyl alcohol is a...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

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Phys. Chem. Chem. Phys., 2018, Advance Article DOI: 10.1039/C8CP05404E, PaperEwa Mosiniewicz-Szablewska, Antonia R. Clavijo, Ana P. O. R. Castilho, Leonardo G. Paterno, Marcelo A. Pereira-da-Silva, Jaros ław Więckowski, Maria A. G. Soler, Paulo C. Morais The importance of the substrate surface effects on the magnetic behavior of layer-by-layer assembled polyvinyl alcohol/iron oxide nanofilms is evidenced. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
MPs are demanding a 5p levy on bottles of wine to pay for treating problem drinkers and alcoholics. Increasing alcohol duty by 1% could raise £100million a year and save the NHS money, it is claimed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We reported the organic template-free synthesis of gold (Au) nanoparticles (NPs) supported on TiO2, SiO2, and Al2O3 displaying uniform Au sizes and high dispersions over the supports. The Au-based catalysts were prepared by a deposition –precipitation method using urea as the precipitating agent. In the next step, the solvent-free oxidation of benzyl alcohol was investigated as model reaction using only 0.08–0.05 mol% of Au loadings and oxygen (O2) as the oxidant. Very high catalytic performances (TOF up to 443,624  h−1) could be achieved. Specifically, we investigated their catalytic activities...
Source: European Journal of Applied Physiology - Category: Physiology Source Type: research
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AbstractA procedure for preparation of99Mo/99mTc radioisotope generator based on low specific activity neutron activated99Mo was developed. Aluminum molybdate(VI)-99Mo of high Mo(VI) content (~  364 mg/g Al99Mo) was prepared by mixing low specific activity molybdate(VI)-99Mo and aluminum mixture solution with isoamyl alcohol. Al99Mo gel matrix was precipitated when the pH of the mixture solution was raised to ~  5 by addition of NaOH to the mixture. Radiometric measurements indicate the strong fixation of Molybdate(VI)-99Mo species in the form of the sparingly insoluble Al99Mo gel matrix. The prepared Al...
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Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 October 2018Source: Chinese Journal of Chemical EngineeringAuthor(s): Chunli Li, Cong Duan, Jing Fang, Hongshi LiAbstractReactive distillation (RD) process is an innovative hybrid process combining reaction with distillation, which has recently come into sharp focus as a successful case of process intensification. Considered as the most representative case of process intensification, it has been applied for many productions, especially for production of ester compounds. However, such problems existing in the RD system for ester productions are still hard to solve, as the removal of the...
Source: Chinese Journal of Chemical Engineering - Category: Chemistry Source Type: research
In this study, we present a water-based grafting approach to produce polyvinyl alcohol (PVA) incorporated CNT buckypaper and CNT-graphene hybrid buckypaper composites with enhanced mechanical performance (tensile and fracture) and electrical conductivity. Our approach provides a wide range of composition for CNT (5–77 wt.%) and polymer matrix (23–95 wt.%) without compromising the uniformity of CNT dispersion and polymer matrix homogeneity. The composite buckypapers have lightweight with a density of 168 mg/cc (lighter than daily use copy papers having a density of 740 mg/cc). They show an electrical conduct...
Source: Composites Science and Technology - Category: Science Source Type: research
Research, published in theEuropean Journal of Endocrinology, suggests that diabetes patients may be at a higher risk of death from an accident, alcoholism or suicide due to the psychological burden of managing their disease. Independant
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