New functions in translation termination uncovered for NMD factor UPF3B

Despite a wealth of biochemical data, the mechanism by which targets of the nonsense-mediated mRNA decay (NMD) pathway are recognized during translation termination remains elusive. A new study by Neu-Yilik et al (2017) using a fully reconstituted in vitro translation termination system reveals new roles for the NMD factor UPF3B in translation termination and a direct interaction between UPF3B and ribosome release factors.

Source: EMBO Journal - October 16, 2017 Category: Molecular Biology Authors: Mühlemann, O., Karousis, E. D. Tags: Protein Biosynthesis & Quality Control, RNA Biology News [amp ] Views Source Type: research