Ibrutinib, Fludarabine, Cyclophosphamide, and Obinutuzumab (GA101) (iFCG) Treatment for First-Line Therapy  of Patients with CLL with Mutated IGHV and Without Deletion 17p

CLL, Chemotherapy, Ibrutinib, Frontline Treatment, Mutated IGHV
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research

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Abstract The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression, increasing tumor cell survival and chemoresistance and metastasis to organs with high CXCL12 levels (e.g., lymph nodes and bone marrow (BM)). Furthermore, the overexpression of CXCR4 has been found to have prognostic significance for disease progression in ...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
There is a known association between Hodgkin lymphoma (HL) and autoimmune disorders with several case reports and case series describing diseases such as immune thrombocytopenia (ITP) in patients with HL, as well as population studies depicting a link between these phenomena. The following case report describes a patient initially presenting with ITP and subsequently being diagnosed with HL as well as primary biliary cirrhosis (PBC) and Hashimoto ’s thyroiditis. This case is unique as it is one of only a few case reports describing multiple autoimmune conditions in one patient with HL and in this scenario, the thromb...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
In a first, a national cancer organization has issued formal guidelines recommending exercise as part of cancer treatment, for all cancer patients. The Clinical Oncology Society of Australia (COSA) is very clear on the directive. Its recommendations are: Exercise should be embedded as part of standard practice in cancer care and viewed as an adjunct therapy that helps counteract the adverse effects of cancer and its treatment. All members of the multi-disciplinary cancer team should promote physical activity and help their patients adhere to exercise guidelines. Best practice cancer care should include referral to an accr...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Exercise and Fitness Health Source Type: blogs
Abstract Severe thrombocytopenia (≤50x109 platelets/L) due to hematological malignancy and intensive chemotherapy is associated with an increased risk of clinically significant bleeding. Since the bleeding risk is not linked to the platelet count only, other hemostatic factors must be involved. In 77 patients with acute leukemia, multiple myeloma or malignant lymphoma, who experienced chemotherapy-induced thrombocytopenia, we studied platelet function. Platelets from all patients - independent of disease or treatment type - were to a variable extent compromised in Ca2+ flux, integrin αIIbβ3 activatio...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
1416Objectives: Our aim was to study the prognostic value of two new FDG PET biomarkers in diffuse large B-cell lymphoma (DLBCL). The first one is the total tumor surface (TTS), describing the tumor-host interface. The second one is the tumor volume surface ratio (TVSR), corresponding to the ratio between the total metabolic tumor volume (TMTV) and TTS, describing the tumor fragmentation. Methods: 215 patients with DLBCL were retrospectively included. The International Prognostic Index (IPI) was established. Patients underwent initial FDG PET/CT before R-CHOP (73%) or intensified R-CHOP (R-ACVBP) regimen (27%). TMTV was me...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
1417Objectives: To analyze the relationship between the SUVmax decrease proportion(SUVmax% )and MYC gene in diffuse large B-cell lymphoma (DLBCL), and evaluate the prognostic value on 18F-FDG PET/CT imaging and MYC gene in DLBCL. To study the SUVmax% and Deauville 5-point scale in the different phase of chemotherapy and reserch the optimal time point . Methods 171 patients (87 males, 84 females, average age 50.66±2.56 (12-81) years) with pathologically confirmed DLBCL were analyzed. 18F-FDG PET/CT were performed before and after different courses of chemotherapy (60 patients in early phase, 55 patients in medium pha...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
1418Objectives: To evaluate the prognostic value of the SUVmax decrease proportion (SUVmax%) and Deauville 5-point scale(D-5PS) on PET/CT imaging and the MYC gene rearrangement during early chemotherapy in patients with diffuse large B-cell lymphoma (DLBCL). Methods: Sixty primary diagnosed patients (29 males, 31 females, average age of 51±2 (12-81) years) with pathologically confirmed DLBCL were analyzed. 18F-FDG PET/CT was performed before and after 1 or 2 cycles of chemotherapy (30 patients each). The region of interest (ROI) was drawn, and the SUVmax% was calculated. Patients were evaluated using the D-5PS. Fluo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
Conclusions: 18F-FDG PET / CT helps to make FL patient’s treatment decisions by suggesting histological large cell transformation, clarifying clinical staging and finding treatment indications.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
Conclusion: In present study in a small number of patients neither MTV nor TLG were predictive outcome parameters. Current results do not support recently published scarce literature data regarding the role of quantitative PET/CT parameters in PTCL. In view of these controversial results further studies in a large number of patients are needed to determine whether quantitative functional PET/CT parameters such as MTV and TLG could be used for precise prediction of outcome in patients with PTCL.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
Conclusion F-18 FDG PET/CT showed higher SUVmax in patients with histopathological transformation than those without transformation, and could also track the CD response to chemotherapy, which demonstrated PET/CT may be a useful tool in monitoring of chemotherapeutic response and surveillance of histopathological transformation of CD. Key words Castleman’s disease, F-18 FDG, PET/CT
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Leukemia/Lymphoma/Myeloma Poster Session Source Type: research
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