Common TDP1 polymorphisms in relation to survival among small cell lung cancer patients: a multicenter study from the International Lung Cancer Consortium.

CONCLUSIONS: We found the rs942190 GG genotype to be associated with relatively poor survival among SCLC patients. Further investigation is needed to confirm the result and to determine whether this genotype may be a predictive marker for treatment efficacy of DNA topoisomerase inhibitors.
PMID: 28974547 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 3, 2017 Category: Cancer & Oncology Authors: Lohavanichbutr P, Sakoda LC, Amos CI, Arnold SM, Christiani DC, Davies MPA, Field JK, Haura EB, Hung RJ, Kohno T, Landi MT, Liu G, Liu Y, Marcus MW, O'Kane GM, Schabath MB, Shiraishi K, Slone SA, Tardon A, Yang P, Yoshida K, Zhang R, Zong X, Goodman GG, W Tags: Clin Cancer Res Source Type: research