Does Timing, Duration, Dose, and Route of Corticosteroids Matter in Prevention of Postextubation Stridor?
No abstract available
ConclusionsOur real-life experience in biologic-na ïve CD patients demonstrated that patients started on IFX were more likely to have a harder-to-treat phenotype. Despite that, efficacy end points were similar between both groups. Clinical remission was higher in patients with combination therapy for IFX, but not for those on ADA. This warrants fur ther investigation.
In conclusion, quercetin restores corticosteroid sensitivity, and has the potential to be a novel treatment in combination with corticosteroids in COPD. PMID: 29227717 [PubMed - as supplied by publisher]
CONCLUSIONS: The prevalence and severity of RW during the first year of life remained high over time, with remarkably high rates of ED visits, admissions for wheezing and use of asthma medications. This study suggests the need for considering early asthma diagnosis and to establish an appropriate treatment in infants with recurrent and severe asthma-like symptoms. PMID: 29231772 [PubMed - as supplied by publisher]
Condition: Lumbosacral Radicular Pain Interventions: Drug: SP-102; Drug: Placebo Sponsors: Semnur Pharmaceuticals, Inc.; Worldwide Clinical Trials Recruiting
Conditions: Allogeneic Disease; GVH - Graft Versus Host Reaction; GVHD, Acute; Stem Cell Transplant Complications Interventions: Drug: Methotrexate; Drug: Placebo Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting
Condition: Persistent ARDS Interventions: Drug: Methylprednisolone; Drug: Methylprednisolone placebo Sponsor: Assistance Publique Hopitaux De Marseille Not yet recruiting
If you’re an athlete taking the WADA allowed 1600 micrograms of salbumatol each day that’s the equivalent of 16 doses from a standard metered dose inhaler. If you’re taking so much that it leads to you failing a drug test, then you have serious problems. Most lay people take two doses at a time to relieve symptoms, such as chest tightness, coughing, wheezing and breathlessness, so that’s still using the stuff 8 times a day. I wonder though, whether you are an athlete or not, if you need to take that much bronchodilator each day to get relief and a decent peak flow rate, then it’s odd that you...
We describe the first case of SIADH and NSD associated with low-risk myelodysplastic syndrome that was successfully treated with corticosteroids and cyclosporine. The patient has remained stable for 1 year without any recurrence. PMID: 29225251 [PubMed - as supplied by publisher]
Lebrikizumab did not significantly improve FEV1 in mild-to-moderate asthma patients at a dose expected to inhibit the IL-13 pathway. Inhibiting IL-13 in this patient population was not sufficient to improve lung function. These data support the findings of a previous trial of lebrikizumab in patients not receiving ICS.
Publication date: Available online 12 December 2017 Source:Steroids Author(s): J.D. Caldwell, K. Londe, S.D. Ochs, Z. Hajdu, A. Rodewald, V.M. Gebhart, G.F. Jirikowski Steroid-binding globulins (SBGs) such as sex hormone binding globulin, corticosteroid binding globulin, and vitamin-D binding protein are receiving increasing notice as being actively involved in steroid actions. This paper reviews data of all three of these SBGs, focusing on their presence and possible activity in the brain and nose. We have found all three proteins in the brain in limbic areas such as the paraventricular (PVN) and supraoptic nuclei (SON) ...