Novel freeze-dried DDA and TPGS liposomes are suitable for nasal delivery of vaccine

This study has shown that the novel liposomes have potential for development as a mucosal vaccine delivery system. Furthermore, the stability of the lyophilized liposomes offers potential additional benefits in terms of thermal stability over liquid formats. Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

Related Links:

Source: BMJ News - Category: General Medicine Source Type: research
In this study, we used bacterium-like particles (BLPs) as carriers and different copy numbers of the Aβ 1-6 peptide as epitopes to design four Aβ active immunization vaccines. The epitopes containing different copy numbers of the Aβ 1-6 peptide were specifically loaded on the surface of BLPs via fusion with a peptidoglycan anchoring domain. These four BLP-based Aβ vaccines successfully induced high levels of Aβ42-specific antibodies in mice. However, none of the vaccines induced a T-cell-mediated immune response. Importantly, the antibodies induced by these four vaccines were effective in blocking ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
YELLOW fever vaccine may be the last thing on many holidaymakers ’ minds before they vacate to their exotic destination, but the jab can stop you getting the disease particularly if you’re travelling to an area where the infection is found. How long does the vaccination last and when do you need to get it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: October 2018Source: Fish &Shellfish Immunology, Volume 81Author(s): Shu-Ying Feng, Gao-Feng Liang, Zheng-Shun Xu, Ai-Fang Li, Jing-Xia Du, Guan-Nan Song, Shai-Yu Ren, Yu-Lin Yang, Guanglong JiangAbstractCurrently, white spot syndrome virus (WSSV) is one of the most serious pathogens that impacts shrimp farming around the world. A WSSV vaccine provides a significant protective benefit to the host shrimp. Although various types of vaccines against WSSV have emerged, the immune effects among them were not compared, and it remains unclear which type of vaccine has the strongest protective effect. Meanwhil...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: August 2018Source: Peptides, Volume 106Author(s): Han-Ning Huang, Chieh-Yu Pan, Jyh-Yih ChenAbstractPicornavirus is a highly contagious virus that usually infects cloven hoofed animals and causes foot-and-mouth disease. This disease is a major threat to livestock breeding worldwide and may lead to huge economic losses. Because effective vaccines or antiviral drugs remain unavailable, the search for new agents to combat FMDV infections is ongoing. Antimicrobial peptides are known to possess a broad range of biological activities, including antibacterial, antiviral, antitumor and immunomodulatory effects. I...
Source: Peptides - Category: Biochemistry Source Type: research
YELLOW fever vaccine may be the last thing on many holidaymakers ’ minds before they vacate to their exotic destination, but the jab can stop you getting the disease particularly if you’re travelling to an area where the infection is found. How long does the vaccination last and when do you need to get it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Public Health England today admitted the jab had 'no significant effectiveness ’ in stopping people being struck down by H3N2, which was blamed for adding to the pressure on the NHS.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Rasool MH, Rafiq A, Nawaz MZ, Shafique M, Saqalein M Abstract Comparative cross sectional study was conducted on blood samples (n = 231) collected from children of 1 to 10 years of age in Punjab Pakistan through convenient sampling method. Indirect haemagglutination assay (IHA) was standardized and used for serodiagnosis and evaluation of humoral immunity against measles. Associated risk factors including age, gender, locale, and vaccination status were analyzed. Geometric mean titre (GMT) of vaccinated individuals was significantly higher (p
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
This study revealed, through environmental monitoring, the introduction of SL PVs into the population associated with the routine use of OPV in Poland before the April 2016. Our findings demonstrate the usefulness of environmental surveillance in the overall polio eradication program. PMID: 30015429 [PubMed - in process]
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
Authors: Leung C, Münz C, Riemer A PMID: 30009188 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
More News: Drugs & Pharmacology | Study | Vaccines