Involvement of connexin 43 phosphorylation and gap junctional communication between smooth muscle cells in vasopressin-induced ROCK-dependent vasoconstriction after hemorrhagic shock

In conclusion, AVP-mediated vascular contractile effects are endothelium and myoendothelial gap junction independent. Gap junctions between VSMCs, gap junctional communication, and Cx43 phosphorylation at Ser262 play important roles in the vascular effects of AVP. RhoA/ROCK, but not PKC, is involved in this process.

Source: AJP: Cell Physiology - October 1, 2017 Category: Cytology Authors: Yang, G., Peng, X., Wu, Y., Li, T., Liu, L. Tags: RESEARCH ARTICLE Source Type: research