Xhance ™ (fluticasone propionate) for the Treatment of Nasal Polyps

Xhance ™ (fluticasone propionate / previously known as OPN-375), a synthetic trifluorinated corticosteroid, is indicated for the treatment of nasal polyps in patients aged 18 years or older.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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ConclusionOur prospective findings validate the potential value of sinus CT scan in predicting GC-sensitivity in CRSwNP patients.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: This study provides detailed information that facilitates studying CRS and its main phenotypes. However, patient distribution of this study does not necessarily reflect disease distribution in the general population. PMID: 29911211 [PubMed - as supplied by publisher]
Source: Rhinology - Category: ENT & OMF Tags: Rhinology Source Type: research
Abstract To evaluate the efficacy of a dermoplasty technique in controlling nasal polyps comparing to the conventional endoscopic approach. Prospective observational study Tertiary private hospital. Twenty-nine patients underwent surgery for replacement of the middle meatus mucosa with skin. Some patients (41.4%) suffered from allergies, 44.8% from asthma, and 27.6% from aspirin intolerance. Polyps were staged according to the Lildholdt system, and patients completed a sino-nasal outcome test (SNOT-22) pre and post-operatively. Also, patients were interrogated as for medication relevant to the nose received pre and post-...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
Conclusion: To our knowledge, our study discusses the factors involved in the pathogenesis, clinical symptoms, diagnosis, treatment, and management of patients. This review can provide recommended strategies in a comprehensive and targeted vision for patients suffering from this syndrome.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Intersect ENT, based in Menlo Park, California, is releasing in the U.S. its SINUVA sinus implant for treating nasal polyp disease in adults that underwent previous surgical sinus procedures. The device elutes mometasone furoate, a corticosteroi...
Source: Medgadget - Category: Medical Devices Authors: Tags: ENT Source Type: blogs
Follow me on Twitter @RobShmerling Let us sing the praises of good medical screening tests. These are the tests that can detect medical problems before they become untreatable and before they cause complications or even death. Even better are those screening tests that detect “predisease” — abnormalities that aren’t dangerous on their own but can lead to problems later. According to the US Preventive Services Task Force, relatively few screening tests are considered good enough to routinely recommend for adults, including mammography for breast cancer (women) Pap smear for cervical cancer (women) b...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Health Prevention Screening Source Type: blogs
We report the effect of EDS-FLU on QoL as measured by the Rhinosinusitis Disability Index (RSDI).
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Abstract BACKGROUND: Despite adding Omalizumab to conventional therapy, several severe asthmatics still show poor disease control. We investigated the factors that may affect a reduced Omalizumab response in a large population of severe asthmatics. METHODS: 340 patients were retrospectively evaluated. FEV1%, FVC%, Asthma Control Test (ACT), fractional exhaled nitric oxide (FENO), possible step-downs/step-ups of concomitant therapies, exacerbations, disease control levels, ICS doses and SABA use, observed at the end of treatment, were considered as a response to Omalizumab. RESULTS: Age was an independent...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
Oral corticosteroids are commonly used in the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP).1 However, the efficacy of oral-corticosteroid therapy varies between different patients with CRSwNP. IL-25 –mediated TH2-biased response is reported to be associated with corticosteroid sensitivity in airway inflammatory response,2 while their value for predicting oral-corticosteroid response to CRSwNP has not been completely evaluated.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
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