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Xhance ™ (fluticasone propionate) for the Treatment of Nasal Polyps

Xhance ™ (fluticasone propionate / previously known as OPN-375), a synthetic trifluorinated corticosteroid, is indicated for the treatment of nasal polyps in patients aged 18 years or older.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
ConclusionSignificant improvements over a range of subjective and objective endpoints, including a reduction in the need for sinus surgery by 61%, suggest that MF sinus implants may play an important role in management of recurrent NP.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusion: In CRSwNP pts with asthma, DPL significantly improved all asthma-related items. Improvement correlated with reduced nasal polyp burden.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
ConclusionsThese results suggest that the addition of montelukast to INCS should not be recommended in the treatment of postoperative CRSwNP patients. Level of Evidence1b Laryngoscope, 2017
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Allergy/Rhinology Source Type: research
ConclusionsAn international effort in the implementation of SUA patients registries could help to better understand the clinical features and to manage severe asthma, representing a non negligible socio‐economic burden for health services.This article is protected by copyright. All rights reserved.
Source: Allergy - Category: Allergy & Immunology Authors: Tags: Original Article: Airway Diseases Source Type: research
Abstract ObjectivesAccording to clinical and comissioning guidelines for chronic rhinosinusitis (CRS), patients being referred to secondary care should have failed primary medical treatment with nasal douching (ND) and intranasal corticosteroids (INCS). The study objectives were to identify the rate of specific medical therapy in CRS patients and establish any differences in medication use, for both CRS and associated medical conditions, between CRS phenotypes. Design and settingCase‐control study in a secondary care setting. MethodsParticipant‐reported study‐specific questionnaire capturing free text data on current...
Source: Clinical Otolaryngology - Category: ENT & OMF Authors: Tags: Original Article Source Type: research
Conclusions A set of typical clinical parameters has a superior accuracy in prediction of AERD diagnosis than the measurement of uLTE4 concentration alone. The addition of uLTE4 concentration to clinical parameters slightly enhances the prediction of AERD diagnosis, especially due to a high NPV.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ObjectiveWe sought to establish the significance of querying chronic rhinosinusitis (CRS) patients about their past CRS‐related oral antibiotic and corticosteroid usage by determining the association between these metrics and patients' quality of life (QoL). Study DesignCross‐sectional study. MethodsA total of 157 patients with CRS were prospectively recruited. CRS‐specific QoL was measured using the 22‐item Sinonasal Outcome Test (SNOT‐22). General health‐related QoL was measured using the EuroQoL five‐dimensional questionnaire visual analog scale. Associations were sought between these measures of QoL and f...
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Allergy/Rhinology Source Type: research
Conclusions Almost all patients with difficult-to-control asthma have comorbidities, in particular asthmatic women of older age, former smokers, and asthmatics who are prednisone dependent. Recognition of these typical characteristics can help physicians in the diagnostic workup, so that adequate preventive measures can be taken.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Conclusion: Inflammatory pseudotumor of the temporal bone can cause devastating effects on neurological function and quality of life. Recognition of characteristic imaging and histopathology can expedite appropriate treatment. Patients may require chronic steroid therapy. Adjunctive therapy with radiation and immuno-modulation are currently being explored.
Source: Otology and Neurotology - Category: ENT & OMF Tags: Tumors of the Ear and Cranial Base Source Type: research
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