TLR7/8 agonists stimulate plasmacytoid dendritic cells to initiate a Th17-deviated acute contact dermatitis in humans

Stimulation of TLR7/8 in human skin induces an acute contact dermatitis with pDC as primary sensors and IL-23 as essential driver of the reaction, thus constituting a standardized, but limited model of human psoriasis.

Source: Journal of Allergy and Clinical Immunology - September 19, 2017 Category: Allergy & Immunology Authors: Natalie Garzorz-Stark, Felix Lauffer, Linda Krause, Jenny Thomas, Anne Atenhan, Regina Franz, Sophie Roenneberg, Alexander Boehner, Manja Jargosch, Richa Batra, Nikola S. Mueller, Stefan Haak, Christina Gro ß, Olaf Groß, Claudia Traidl-Hoffmann, Fabian Source Type: research