Effects of water extractable phytochemicals of mahogany (Swietenia macrophylla) and axlewood (Anogeissus leiocarpus) stem bark on some enzymes implicated in erectile dysfunction and type ‐2 diabetes

This study was designed to investigate the effect of Swietenia macrophylla (SM) and Anogeissus leiocarpus (AL) extracts on enzymes relevant to erectile dysfunction (phosphodiesterase‐5 and arginase) and type‐2 diabetes (α‐amylase and α‐glucosidase), assess their antioxidant potential and characterize their phenolic constituents. The results revealed that extracts inhibited α‐amylase and α‐glucosidase, with AL having higher α‐amylase inhibitory properties (IC50 = 223.41 µg/mL) than SM (IC50 = 293.90 µg/mL). Also, the extracts inhibited both phosphodiesterase‐5 and arginase in dose‐dependent manner in vitro; nevertheless, AL showed higher inhibition [phosphodiesterase‐5 (IC50 = 174.19 µg/mL); arginase (38.01 µg/mL)] than SM [phosphodiesterase‐5 (IC50 = 470.66 µg/mL); arginase (54.25 µg/mL)]. In addition, the extracts possess antioxidant properties and HPLC analysis of phenolic constituents revealed the presence of gallic acid, catechin, ellagic acid, and quercetin. However, the results suggest that AL and SM could offer a therapeutic source of erectogenic and anti‐diabetic agents. Practical applicationsThe data generated in this study suggest that axlewood stem and mahogany stem bark could be useful in the management of diabetes and erectile dysfunction. In addition, isolation and identification of active components of these plants could represent a novel nutraceutical with erectogenic and anti‐diabetic potential that has the...
Source: Journal of Food Biochemistry - Category: Food Science Authors: Tags: FULL ARTICLE Source Type: research