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Psychogenic Non-epileptic Seizures and Conversion Disorder Psychogenic Non-epileptic Seizures and Conversion Disorder

Should psychogenic non-epileptic seizures be considered a distinct diagnosis, separate from conversion disorder?Journal of Neurology, Neurosurgery, and Psychiatry
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news

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This study aimed to investigate the incidence of aggressiveness in patients with severe drug-refractory focal epilepsy (DRE) who started perampanel (PER) as add-on treatment, and to identify possible predisposing factors. Data on 49 consecutive patients with severe DRE who initiated PER were retrospectively collected. Twelve of the 49 patients experienced aggressiveness as adverse event related to PER treatment, one third of them on low (2-4 mg/day) PER dosages. PER was discontinued in 10/12 patients because of aggressive behaviors. Aggressiveness could appear after several months or even more than one year of PER treatmen...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
Although there is no strict consensus, some studies have reported that Postictal generalized EEG suppression (PGES) is a potential electroencephalographic (EEG) biomarker for risk of sudden unexpected death in epilepsy (SUDEP). PGES is an epoch of EEG inactivity after a seizure, and the detection of PGES in clinical data is extremely difficult due to artifacts from breathing, movement and muscle activity that can adversely affect the quality of the recorded EEG data. Even clinical experts visually interpreting the EEG will have diverse opinions on the start and end of PGES for a given patient. The development of an automat...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Authors: Curatolo P, Moavero R, van Scheppingen J, Aronica E Abstract INTRODUCTION: The mammalian target of rapamycin (mTOR) pathway has emerged as a key player for proper neural network development, and it is involved in epileptogenesis triggered by both genetic or acquired factors. Areas covered. The robust mTOR signaling deregulation observed in a large spectrum of epileptogenic developmental pathologies, such as focal cortical dysplasias and tuberous sclerosis complex (TSC), has been linked to germline and somatic mutations in mTOR pathway regulatory genes, increasing the spectrum of "mTORopathies". The ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
ObjectiveIncreasing evidence has suggested that epilepsy is a network disease. Graph theory is a mathematical tool that allows for the analysis and quantification of the brain network. We aimed to evaluate the influences of duration of epilepsy on the topological organization of brain network in focal epilepsy patients with normal MRI using the graph theoretical analysis based on diffusion tenor imaging. MethodsWe prospectively enrolled 66 patients with focal epilepsy (18/66 patients were newly diagnosed) and 84 healthy subjects. All of the patients with epilepsy had normal MRI on visual inspection. All of the subjects und...
Source: Acta Neurologica Scandinavica - Category: Neurology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: In adults and children with epilepsy use of carbamazepine is associated with a decrease of folate, valproic acid with a rise in the vitamin B12 level, and carbamazepine with an increase in homocysteine. Valproic acid showed only in children an association with the rise of the homocysteine level. Psychiatrists may find it advisable to control the levels of folate and homocysteine in adults and children who are taking carbamazepine and to measure homocysteine level in children taking valproic acid. PMID: 29341053 [PubMed - in process]
Source: Tijdschrift voor Psychiatrie - Category: Psychiatry Authors: Tags: Tijdschr Psychiatr Source Type: research
(Wyss Center for Bio and Neuroengineering) The Wyss Center, a non-profit neurotechnology translation organization, has signed a partnership agreement with German medical engineering company, CorTec. The partners will work together on research, design and development of a device for continuous, long-term, monitoring of the brain's electrophysiological signals for clinical diagnostic and therapeutic applications. The planned device will sit on the skull, beneath the skin and has potential uses in epilepsy monitoring, tinnitus regulation through neurofeedback, neuromodulation for dyslexia and other brain circuit disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Causes of post-stroke epilepsy are manifold and not just restricted to the stroke itself (primary post-stroke epilepsy). These causes range from premorbid conditions already present before the stroke, to morbidity that develops after the stroke, either as a complication of, or independent of, the stroke. Seizures associated with a pre-existing disposition (eg, meningitis, head trauma, or encephalopathy caused by, for example, diabetes or hypertension) can be triggered by stroke or by co-pathologies developing after a stroke (secondary post-stroke epilepsy).
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research
We describe four cases of GAD antibody-related autoimmune encephalitis. Three of them had extralimbic involvement and only one had limbic encephalitis.
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Publication date: February 2018 Source:The Lancet Neurology, Volume 17, Issue 2 Author(s): Josef Finsterer
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: February 2018 Source:The Lancet Neurology, Volume 17, Issue 2 Author(s): Marian Galovic, Nico Döhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Julian Conrad, Stefan Evers, Michael Winklehner, Tim J von Oertzen, Hans-Peter Haring, Anna Serafini, Giorgia Gregoraci, Mariarosaria Valente, Francesco Janes, Gian Luigi Gigli, Mark R Keezer, John S Duncan, Josemir W Sander, Matthias J Koepp, Barbara Tettenborn Background Stroke is one of the leading causes of acquired epilepsy in adults. An instrument to predict whether people are at high risk of developing post-stroke seizures is n...
Source: The Lancet Neurology - Category: Neurology Source Type: research
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