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Psychogenic Non-epileptic Seizures and Conversion Disorder Psychogenic Non-epileptic Seizures and Conversion Disorder

Should psychogenic non-epileptic seizures be considered a distinct diagnosis, separate from conversion disorder?Journal of Neurology, Neurosurgery, and Psychiatry
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry Journal Article Source Type: news

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CONCLUSIONS: There may be differences between the F20-29 and F30-39 groups and their family members regarding risk for diseases affecting the immune system. This is in line with different activity of the immune system measured in blood for the disorders and may add information regarding etiology and pathology of these psychiatric diseases. Further studies including a greater number of subjects, as well as confirmation of the immunological diseases through blood samples are needed. PMID: 29141491 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Epilepsy and schizophrenia are common and typical neurological or mental illness respectively, and sometimes they comorbid in the same patients, however the underlying genetic relationship between the two brain diseases is still not fully understood. To investigate the possible genetic contribution to their comorbidity, we performed polygenic risk score (PRS) analyses and genetic correlation estimation so as to identify the overall genetic overlap between the two diseases. The global schizophrenia PRS is strongly associated with schizophrenia phenotype in Hong Kong population (odds ratio = 1.7, p =&thi...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - Category: Genetics & Stem Cells Authors: Tags: RESEARCH ARTICLE Source Type: research
We describe 18 new individuals with heterozygous sequence variations in PURA. A neuromotor disorder starting with neonatal hyptonia, but ultimately allowing delayed progression to walking, was present in nearly all individuals. Congenital apnea was present in 56% during infancy, but all cases in this cohort resolved during the first year of life. Feeding difficulties were frequently reported, with gastrostomy tube placement required in 28%. Epilepsy was present in 50% of the subjects, including infantile spasms and Lennox–Gastaut syndrome. Skeletal complications were found in 39%. Disorders of gastrointestinal motili...
Source: American Journal of Medical Genetics Part A - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: 2018 Source:Biocybernetics and Biomedical Engineering, Volume 38, Issue 1 Author(s): Saba Ajami, Amin Mahnam, Vahid Abootalebi Brain–computer interfaces based on steady-state visual evoked potentials have recently gained increasing attention due to high performance and minimal user training. Stimulus frequencies in the range of 4–60Hz have been used in these systems. However, eye fatigue when looking at low-frequency flickering lights, higher risk of induced epileptic seizure for medium-frequency flickers, and low signal amplitude for high-frequency flickers complicate appropriate selection o...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Condition:   Epilepsy Intervention:   Sponsor:   Theusinger Oliver M. Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Schulze-Bonhage A Abstract INTRODUCTION: Focal epilepsy is the most common type of epilepsy with approximately 30 million patients affected worldwide. There is a major challenge to develop new antiepileptic treatments as currently approximately one third of patients remain uncontrolled under our best standards of care. Areas covered: An overview is given on first- and second generation antiepileptic drugs and their mechanisms of action, and on recent new strategies for antiepileptic targets, including drugs aiming at disease modification. Expert opinion: Newer antiepileptic drugs have enabled a better tole...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ClC-4 is an intracellular Cl−/H+ exchanger that is highly expressed in the brain and whose dysfunction has been linked to intellectual disability and epilepsy. Here we studied the subcellular localization of human ClC-4 in heterologous expression systems. ClC-4 is retained in the endoplasmic reticulum (ER) upon overexpression in HEK293T cells. Co-expression with distinct ClC-3 splice variants targets ClC-4 to late endosome/lysosomes (ClC-3a and ClC-3b) or recycling endosome (ClC-3c). When expressed in cultured astrocytes, ClC-4 sorted to endocytic compartments in WT cells but was retained in the ER in Clcn3−/&m...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Cell Biology Source Type: research
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
Conclusion This study in healthy recreational CNS depressant users showed that single doses of brivaracetam 50mg (therapeutic single dose) had lower sedative, positive, and negative drug effects than alprazolam, while brivaracetam 200 and 1000mg (supratherapeutic single doses) were more similar to alprazolam. The subjective profile of brivaracetam appeared to be similar to that of levetiracetam, but further evaluation using a range of levetiracetam doses would be needed to confirm similar abuse potential.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: February 2018 Source:Biomedical Signal Processing and Control, Volume 40 Author(s): Salim Lahmiri The number of people affected by epilepsy is growing. Therefore, the design of accurate automated systems for detection and classification of electroencephalogram (EEG) signals of epileptic patients is a great aid in the diagnosis process. The purpose of this study is to present an accurate and fast automated diagnosis system to distinguish between normal and abnormal EEG records with seizure free intervals. The system is based on generalized Hurst exponent estimates at different scales used to characterize ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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