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Clues to MS May Lurk in Gut Bacteria

TUESDAY, Sept. 12, 2017 -- Certain types of bacteria in the gut may play a role in the progression of multiple sclerosis, according to researchers working with mice. The research, the study authors believe, could lead to new ways to treat multiple...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Abstract: Despite frequent muscle strength or muscle oxidative capacity (based on exercise-onset oxygen uptake [VO2] kinetics) assessments in patients with multiple sclerosis, the impact of time of day on these parameters is often not taken into account. Based on observations in healthy subjects, it remains to be studied whether muscle strength, and/or exercise-onset VO2 kinetics, varies between the morning and the afternoon in patients with multiple sclerosis. In this prospective observational pilot study, walking capacity, exercise-onset VO2 kinetics, isometric knee extension/flexion strength (dynamometry), and self-repo...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Short Communications Source Type: research
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - Category: Cytology Authors: Tags: REVIEW ARTICLE Source Type: research
Richard Wurtman
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
(Graz University of Technology) Illnesses such as cancer and multiple sclerosis may also be associated with lipids. Disorders are difficult to assess due to the diversity of lipids. Austrian scientists from Graz present a new tool for the analysis of lipids in Nature Methods.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
As a neuropsychologist specializing in cognitive impairment in multiple sclerosis, I divide my time between research and clinical work with patients with multiple sclerosis. Four years ago, Paul Tunick, MD, came to me for a cognitive evaluation. Like so many people with multiple sclerosis, Paul struggled with severe depression, debilitating fatigue, and progressive physical disability that limited his ability to live the full, stimulating life he had known until recently. Paul made his career as an accomplished cardiologist at a major medical center in New York City, and he had an impressive life story. Accepted to Princet...
Source: JAMA Neurology - Category: Neurology Source Type: research
Early clinical suspicion for CNS lymphoma is important for appropriate diagnosis and treatment in patients with preexisting multiple sclerosis (MS).
Source: Neurology - Category: Neurology Authors: Tags: Primary brain tumor, Multiple sclerosis RESIDENT AND FELLOW SECTION Source Type: research
Conclusions: In our small cohort, teriflunomide treatment affects mainly and significantly on B-cell numbers, while having a milder effect on T-cell numbers. Larger cohorts are necessary to confirm these findings and understand the effect of teriflunomide on the functionality of these cells.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Immunology, All Clinical Neurology, Multiple sclerosis Article Source Type: research
In recent years, there has been a significant increase in the therapeutic options available for the management of relapsing forms of MS. Therapies primarily targeting B cells, including therapeutic anti-CD20 monoclonal antibodies, have been evaluated in phase I, phase II, and phase III clinical trials. Results of these trials have shown their efficacy and relatively tolerable adverse effect profiles, suggesting a favorable benefit-to-risk ratio. In this review, we discuss the pathogenic role of B cells in MS and the rationale behind the utilization of B-cell depletion as a therapeutic cellular option. We also discuss the d...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Immunology, Autoimmune diseases, All Demyelinating disease (CNS), Multiple sclerosis, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Views [amp ] Reviews Source Type: research
Unfortunately, the online published article has errors in Table  2. The Peginterferon is listed as IM, when it should be SC.
Source: Journal of Neurology - Category: Neurology Source Type: research
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