HRT news: Hormone replacement therapy 'slashes risk of early death in middle aged women'
HORMONE replacement therapy slashes a middle aged woman's risk of an early death by almost a third, according to new research.
Conclusions Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations.
Conclusions: Lifestyle factors, such as HRT and smoking are differentially associated with the risk of MSI-H and MSS CRC. Further research on associations of lifestyle factors and CRC subtypes is necessary to provide a better understanding of the CRC disease pathway. PMID: 29438474 [PubMed - as supplied by publisher]
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New determinants for gallstone disease? . Dan Med J. 2018 Feb;65(2): Authors: Shabanzadeh DM Abstract Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A smal...
CONCLUSION: TM is associated with both hypersensitivity and a bleeding tendency. This study revealed no significant increase in the incidence of haemostatic abnormalities in patients with TM compared with the control group. Given the significant association with hypersensitivity disorders, the underlying mast cell hyper-reactivity may contribute to both hypersensitivity and a bleeding tendency and predispose patients to TM. PMID: 29409702 [PubMed - as supplied by publisher]
AbstractRationale:Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations – including spastic diplegia, deterioration in cognitive function, and epilepsy – appear in later childhood.Patient concerns:A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy. Seven years later (at 10 years old), he presented with spastic diplegia, cognitive function lesions, epi...
Conclusions: This patient reported a considerable improvement in all the outcome measures. She completed the treatment after experiencing great improvement in her QoL. Additional, larger-scale studies are warranted to investigate the effects of ICBA. PMID: 29410721 [PubMed]
This article outlines the symptoms of the menopause and the available treatments for these, including hormone replacement therapy, non-hormonal treatments and alternative therapies, and discusses how nurses can assist women undergoing the menopause to improve their health and quality of life during this often challenging time. PMID: 29363891 [PubMed - in process]
Abstract Considerable controversy exists regarding the safety of elective exogenous hormonal exposure among breast cancer survivors and women at high risk of developing the disease (referred to herein as 'previvors'). We performed a qualitative analysis focused on four areas of potential exogenous exposure to hormones among previvors and survivors: hormonal contraception; systemic hormone-replacement therapy (HRT); localized HRT; and hormonal manipulation for fertility preservation or enhancement. Herein, we discuss the available data and present clinical recommendations regarding the safety of hormonal exposure f...