Two new iridoid glycosides from Odontonema cuspidatum and their bioactivities

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): M.S. Refaey, Ahmed M.M. Hassanein, Mahmoud A.H. Mostafa, Amira S. Wanas, A.A. Ali Two new iridoid glycosides, named 6β-O-methyl-unedoside (1) and 6β-O-methyl-5-deoxythunbergioside (2) along with two known phenyl propanoid glucoside compounds dolichandroside A (3) and verbascoside (4) were isolated from the aerial parts of Odontonema cuspidatum (Nees) Kuntze (Acanthaceae). Structure elucidation of the new compounds was established by interpretation of their 1D and 2D-NMR spectral data by comparing with literatures, HRESIMS and optical activity measurement. The isolated compounds were tested for their in vitro antimicrobial and antimalarial activities. Compound 4 showed a moderate antimicrobial activity against E. coli with IC50 value of 17.5μM in comparing with Vancomycin and Cefotaxime. Graphical abstract

Source: Phytochemistry Letters - September 10, 2017 Category: Chemistry Source Type: research