Lenalidomide modulates gene expression in human ABC-DLBCL cells by regulating IKAROS interaction with an intronic control region of SPIB

• Mechanism of action of lenalidomide in ABC-DLBCL is not understood• SPIB is transcriptionally downregulated by lenalidomide• Lenalidomide-induced cell death in ABC-DLBCL involves SPIB downregulation• Lenalidomide-induced degradation of IKAROS is required for SPIB downregulation• IKAROS t ranscriptionally activates SPIB
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research