311 Group 3 innate lymphoid cells (ILC3) induce psoriasiform lesions in human skin xenotransplants in vivo

Psoriasis is thought to be predominantly driven by both CD4+ and CD8+ of the Th17/Tc17 lineages, with an established key role for the Th17 cytokine network, including IL-17 and IL-22. Here, we have explored the possibility that a dysregulation of group 3 innate lymphoid cells (ILC3s) may also be involved in psoriasis pathobiology, by using a modification of our well-established human skin xenotransplant mouse model. Autologous peripheral blood human ILC3s were purified from PBMCs and intradermally injected into normal human skin grafts of healthy donors.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Inflammation, Immunity and Infection Source Type: research