An NF- κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

NF- κB regulates genes essential for conventional T cell activation and function, but its role in Treg cell function remains unclear. Oh et al. use Treg cell-specific conditional deletions of canonical NF-κB subunits to demonstrate central roles for p65 and c-Rel in orchestrating Treg cell developme nt, suppressive function, and molecular identity.

Source: Immunity - September 7, 2017 Category: Allergy & Immunology Authors: Hyunju Oh, Yenkel Grinberg-Bleyer, Will Liao, Dillon Maloney, Pingzhang Wang, Zikai Wu, Jiguang Wang, Dev M. Bhatt, Nicole Heise, Roland M. Schmid, Matthew S. Hayden, Ulf Klein, Raul Rabadan, Sankar Ghosh Tags: Article Source Type: research