The Influence of Cytogenetics on Splenic Response and Survival in Myelofibrosis Patients on JAK Inhibitors

In the era before the advent of JAK inhibitors, cytogenetic information was used to predict overall survival in myelofibrosis (MF) patients. However, its value in predicting clinical response or survival during treatment with JAK inhibitors remains unknown. The purpose of this study is to determine if cytogenetics may have independent effects on therapy response, as measured by splenic reduction, and overall survival.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Vincent Ma, Philip Boonstra, Kamal Menghrajani, Cecelia Perkins, Krisstina Gowin, Moshe Talpaz Tags: Myeloproliferative Neoplasms Source Type: research