Effects of in vivo deletion of GATA2 in bone marrow stromal cells

• GATA2 regulates genes involved in cell adhesion and chemotaxis in BM-MSCs.• Prx1-specific deletion of Gata2 in vivo compromised colony formation capacity.• CMP frequency was decreased by Gata2 deletion in the BM microenvironment.

Source: Experimental Hematology - August 30, 2017 Category: Hematology Authors: Shin Hasegawa, Tohru Fujiwara, Yoko Okitsu, Hiroki Kato, Yuki Sato, Noriko Fukuhara, Yasushi Onishi, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae Source Type: research