Mechanisms of M üller glial cell morphogenesis.

Mechanisms of Müller glial cell morphogenesis.
Curr Opin Neurobiol. 2017 Aug 26;47:31-37
Authors: MacDonald RB, Charlton-Perkins M, Harris WA
Abstract
Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1,2]. However, the molecular cues controlling these developmental steps remain poorly understood. As MG have roles to play in every cellular and plexiform layer, this review discusses our current understanding on how MG morphology may be linked to their function, including the developmental mechanisms involved in MG patterning and morphogenesis. Uncovering the mechanisms governing glial morphogenesis, using transcriptomics and imaging, may provide shed new light on the pathophysiology and treatment of human neurological disorders.
PMID: 28850820 [PubMed - as supplied by publisher]

Source: Current Opinion in Neurobiology - August 26, 2017 Category: Neurology Authors: MacDonald RB, Charlton-Perkins M, Harris WA Tags: Curr Opin Neurobiol Source Type: research