[Correspondence] Combination therapy for carbapenemase-producing Entero-bacteriaceae: INCREMENT-al effect on resistance remains unclear

Bel én Gutiérrez-Gutiérrez and colleagues1 investigated the effect of appropriate combination therapy versus monotherapy on the mortality of patients with bloodstream infections (BSIs) due to carbapenemase-producing Enterobacteriaceae (CPE) in The Lancet Infectious Diseases. In stratified analyses, a ppropriate combination therapy was associated with a significantly lower mortality than was appropriate monotherapy in the high-mortality-score stratum (adjusted hazard ratio 0·56, 95% CI 0·34–0·91; p=0·02), yet the low-mortality-score stratum showed no benefit (adjusted odds ratio 1·21, 0·5 6–2·56; p=0·62).

Source: The Lancet Infectious Diseases - August 24, 2017 Category: Infectious Diseases Authors: Sara E Boyd, Luke S P Moore, Timothy M Rawson, William W Hope, Alison H Holmes Tags: Correspondence Source Type: research