Associations of Tumor Necrosis Factor –α and Interleukin-1β Levels and Polymorphisms with Post-Stroke Depression

Depression frequently occurs in patients with stroke.1 This common comorbidity may be due to the shared biological etiologies of the two disorders, one of which is referred to as the cytokine hypothesis.2 Stroke induces inflammatory reactions, including changes in cytokine activity.3 Proinflammatory cytokines, such as tumor necrosis factor (TNF)- α, interleukin (IL)-1, and IL-6, have been implicated in the initiation and/or amplification of the inflammatory response during acute stroke pathophysiology.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Articles Source Type: research