Medication contaminants as a potential cause of anaphylaxis to vincristine

We report a series of eight patients with adverse reactions to VCR over the course of 11 months at a single institution, four of which progressed to anaphylaxis and one of which resulted in cardiac arrest. Mass spectrometry analysis of medication lots was performed to test for possible contaminant(s). Our findings highlight the risk of anaphylaxis during therapy with VCR.

Source: Pediatric Blood and Cancer - August 22, 2017 Category: Cancer & Oncology Authors: David A. Hill, Allison Barz Leahy, Joseph Sciasci, Sean P. O'Neill, Anne Reilly, Naomi Balamuth, Steven H. Seeholzer, Jonathan M. Spergel, Terri F. Brown ‐Whitehorn Tags: BRIEF REPORT Source Type: research