High doses of vitamin B tied to lung cancer risk, study says

Men who took high doses of vitamin B6 and B12 supplements had a higher risk of lung cancer, and the association was highest among current smokers, according to a study published Tuesday.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Conclusions: While case reports cannot be considered as proof of efficacy, these cases added to others of patients treated with the same method would suggest that this is a viable option for those patients whose disease cannot be treated successfully with other modalities. PMID: 31202206 [PubMed - in process]
Source: Alternative Therapies in Health and Medicine - Category: Complementary Medicine Authors: Tags: Altern Ther Health Med Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Cancer Gene Therapy, Published online: 17 June 2019; doi:10.1038/s41417-019-0114-xA chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
BackgroundThe rationality of selective mediastinal lymph node dissection based on lobe ‐specific metastasis is still controversial. The correlation of lymph node metastasis in lobe‐specific lymphatic drainage regions (LSDRs) and non‐LSDRs has not been widely reported. The purpose of this study was to investigate the variables affecting nodal metastasis in non‐LSDRs and to furt her evaluate the rationality of selective lymphadenectomy in clinical stage IA non‐small cell lung cancer (NSCLC) patients.MethodsThe clinicopathological information of 316 patients with clinical stage IA NSCLC who underwent lobectomy with ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Hille Simon A. Joosse Ronald Simon Markus Tiemann Carsten Bokemeyer Martin Reck Sabine Riethdorf Klaus Pantel Sonja Loges Circulating tumor cells (CTCs) hold great potential to answer key questions of how non-small cell lung cancer (NSCLC) evolves and develops resistance upon anti-PD-1/PD-L1 treatment. Currently, their clinical utility in NSCLC is compromised by a low detection rate with the established, Food and Drug Administration (FDA)-approved, EpCAM-based CellSearch® System. We tested an epitope-independent method (ParsortixTM system) and utilized it to assess PD-L1 expression of CTCs from...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractSmall cell lung cancer (SCLC) is a highly lethal subtype of lung cancer that has seen few therapeutic advances, despite ongoing concerted efforts. Immunotherapy has been an effective option in other carcinogen-related cancers and has shown modest activity in SCLC. Monotherapy with the anti-PD-1 antibody nivolumab in patients with at least two prior lines of therapy was associated with a response rate of 11.9% and a median duration of response of 17.9  months, leading to accelerated approval by the Food and Drug Administration (FDA) as third-line therapy for SCLC. Second-line checkpoint inhibitors have not perf...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Contributors : Yan Zhang ; Yongyue Wei ; Jingjing Ben ; Chen QiSeries Type : Expression profiling by arrayOrganism : Mus musculusMetastasis is the key determinant of poor prognosis for advanced-stage NSCLC patients. Although an important contributor to metastasis is cross-talk between tumor-associated macrophages (TAMs) and tumor cells, its regulation is not fully understood. Expressed primarily in macrophages, scavenger receptor A1 (SR-A1) has been associated with lung tumorigenesis. Here, the mechanistic basis for the involvement of SR-A1 in lung cancer prognosis was investigated using population genetics, transcriptomic...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Publication date: Available online 14 June 2019Source: Personalized Medicine UniverseAuthor(s): Ayaka Nakamura, Minako Abe, Yasuha Ono, Yukie Saeki, Fumika Kono, Hazuki Sakuma, Ayumi Morokuma, Yoshimori Ishihara, Hiroyuki AbeAbstractThe global incidence and mortality rates of colorectal cancer is rising, and has surpassed lung cancer as the highest incidence of all types of cancers in Japan [1]. Standard treatments include surgery and chemotherapy, however immunotherapy using Dendritic Cell (DC) vaccines is also recognized as an effective treatment for many cancers including colorectal cancer. DCs are the most potent antig...
Source: Personalized Medicine Universe - Category: Drugs & Pharmacology Source Type: research
ConclusionThis new method can enable repeatable nationwide measurement of cancer diagnostic timeliness in England and identifies actionable variation to inform early diagnosis interventions and target future research.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
AbstractPurposeBased on an exceptionally durable response to pemetrexed observed in some patients with metastatic NSCLC, the predictive value of pemetrexed sensitivity to outcomes of subsequent systemic treatment was investigated.MethodsWe retrospectively reviewed the patients with metastatic non-squamous NSCLC treated with pemetrexed monotherapy as their first- or second-line chemotherapy between November 2006 and February 2015. Good (top 5% longest) and poor responders (bottom 12% shortest) were defined according to the duration of pemetrexed maintenance. The first and second post-pemetrexed (PP) systemic treatments were...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
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