Severe Hemorrhagic Shock Leads to a Delayed Fracture Healing and Decreased Bone Callus Strength in a Mouse Model.

CONCLUSION: In this in vivo mouse fracture model, we conclude that hemorrhagic shock retards fracture healing during the early phase of the facture healing process.
CLINICAL RELEVANCE: A severe hemorrhagic shock in patients could result in initial delayed fracture healing and needs special attention. We plan to conduct a prospective, observational clinical research study to analyze if delayed fracture healing occurs in patients after severe blood loss.
PMID: 28795328 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - August 9, 2017 Category: Orthopaedics Authors: Bundkirchen K, Macke C, Reifenrath J, Schäck LM, Noack S, Relja B, Naber P, Welke B, Fehr M, Krettek C, Neunaber C Tags: Clin Orthop Relat Res Source Type: research